STRINGSTRING
RGC1 protein (Saccharomyces cerevisiae) - STRING interaction network
"RGC1" - Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator in Saccharomyces cerevisiae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RGC1Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Positive regulator of FPS1 glycerol channel required for the glycerol efflux (1083 aa)    
Predicted Functional Partners:
FPS1
Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress; Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation- under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions (669 aa)
       
 
  0.826
HOG1
Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p an /.../p; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes. Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, [...] (435 aa)
       
 
  0.741
AEP3
Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA; Required for respiration. Stabilizes the mitochondrial bicistronic mRNA encoding ATP6 and ATP8, 2 subunits of the proton- translocating ATP synthase (606 aa)
       
      0.676
ASK10
Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p; Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8 (1146 aa)
       
 
0.657
YCF1
Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; /.../r to human cystic fibrosis protein CFTR; Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates (1515 aa)
       
      0.647
FYV12
Protein of unknown function, required for survival upon exposure to K1 killer toxin; Involved in K1 killer toxin resistance (129 aa)
           
  0.540
YDR034W-B
Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery (51 aa)
           
  0.514
ORM1
Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity (222 aa)
           
  0.457
YLR173W
Putative protein of unknown function (608 aa)
           
  0.440
VPS69
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect; Deletion causes a vacuolar protein sorting defect (106 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
Server load: low (7%) [HD]