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SCD6 protein (Saccharomyces cerevisiae) - STRING interaction network
"SCD6" - Protein containing an Lsm domain in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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Predicted Interactions
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textmining
co-expression
protein homology
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SCD6Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; Suppressor of clathrin deficiency (349 aa)    
Predicted Functional Partners:
DCP2
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5’ cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed-10508173, PubMed-11139489, PubMed-11741542). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m- GDP (PubMed-12554866). Decapping is the major pathway of mRNA degradation in yeast and occurs throu [...] (970 aa)
       
 
  0.987
EDC3
Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Does not affect nonsense-mediated mRNA decay. Required for normal P-body assembly (551 aa)
     
 
  0.968
DHH1
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p inter /.../ith Ngr1p and promotes POR1, but not EDC1 mRNA decay; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1 (PubMed-11780629, PubMed-12032091, PubMed-11696541, PubMed-12730603, PubMed-15703442. PubMed-15706350). Is involved in G1/S DNA-damage checkpoint rec [...] (506 aa)
     
 
  0.941
CDC33
Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (213 aa)
     
 
  0.899
DCP1
Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5’ cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent [...] (231 aa)
       
 
  0.863
LSM12
Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS (187 aa)
           
  0.831
HMT1
Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs) (PubMed-8668183, PubMe [...] (348 aa)
     
 
  0.818
LSM1
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends (172 aa)
           
  0.809
PAT1
Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3’-UTRs from trimming; functionally linked to Pab1p; Activator of decapping that functions as a general and active mechanism of translational repression and required for P- body formation. First decay factor recruited to mRNA, at a time when the mRNA is still associated with translation factors. Subsequently, PAT1 recruits the hepta-heterodimer LSM1-LSM7 complex to P-bodies. In association with the LSM [...] (796 aa)
       
 
  0.784
XRN1
Evolutionarily-conserved 5’-3’ exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5’-3’ exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus p [...] (1528 aa)
     
   
  0.762
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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