| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYB2 | CYC7 | YML054C | YEL039C | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication. | 0.902 |
| CYB2 | HMX1 | YML054C | YLR205C | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | Heme-binding protein HMX1; ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants. | 0.543 |
| CYB2 | OM45 | YML054C | YIL136W | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | 0.656 |
| CYB2 | SUE1 | YML054C | YPR151C | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.519 |
| CYC7 | CYB2 | YEL039C | YML054C | Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.902 |
| CYC7 | SUE1 | YEL039C | YPR151C | Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.513 |
| HMX1 | CYB2 | YLR205C | YML054C | Heme-binding protein HMX1; ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.543 |
| HMX1 | SUE1 | YLR205C | YPR151C | Heme-binding protein HMX1; ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.518 |
| JID1 | SUE1 | YPR061C | YPR151C | J domain-containing protein 1; Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.507 |
| MRX6 | SUE1 | YNL295W | YPR151C | MIOREX complex component 6; Protein that associates with mitochondrial ribosome. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.792 |
| OM14 | OM45 | YBR230C | YIL136W | Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources. | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | 0.939 |
| OM14 | SUE1 | YBR230C | YPR151C | Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.471 |
| OM45 | CYB2 | YIL136W | YML054C | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.656 |
| OM45 | OM14 | YIL136W | YBR230C | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources. | 0.939 |
| OM45 | SPG4 | YIL136W | YMR107W | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | Stationary phase protein 4; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; Belongs to the SPG4 family. | 0.499 |
| OM45 | SUE1 | YIL136W | YPR151C | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.426 |
| SAF1 | SUE1 | YBR280C | YPR151C | SCF-associated factor 1; F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.535 |
| SPG4 | OM45 | YMR107W | YIL136W | Stationary phase protein 4; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; Belongs to the SPG4 family. | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress. | 0.499 |
| SPG4 | SUE1 | YMR107W | YPR151C | Stationary phase protein 4; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; Belongs to the SPG4 family. | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | 0.579 |
| SUE1 | CYB2 | YPR151C | YML054C | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.519 |