node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MET1 | MET10 | YKR069W | YFR030W | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | 0.998 |
MET1 | MET14 | YKR069W | YKL001C | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.951 |
MET1 | MET16 | YKR069W | YPR167C | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Phosphoadenosine phosphosulfate reductase; 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; Belongs to the PAPS reductase family. CysH subfamily. | 0.966 |
MET1 | MET22 | YKR069W | YOL064C | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant; Belongs to the inositol monophosphatase superfamily. | 0.777 |
MET1 | MET28 | YKR069W | YIR017C | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism. | 0.696 |
MET1 | MET3 | YKR069W | YJR010W | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Sulfate adenylyltransferase; ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.943 |
MET1 | MET5 | YKR069W | YJR137C | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.987 |
MET1 | MET8 | YKR069W | YBR213W | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | Siroheme biosynthesis protein MET8; Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. MET8 subfamily. | 0.999 |
MET10 | MET1 | YFR030W | YKR069W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | 0.998 |
MET10 | MET14 | YFR030W | YKL001C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.994 |
MET10 | MET16 | YFR030W | YPR167C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Phosphoadenosine phosphosulfate reductase; 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; Belongs to the PAPS reductase family. CysH subfamily. | 0.998 |
MET10 | MET22 | YFR030W | YOL064C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant; Belongs to the inositol monophosphatase superfamily. | 0.652 |
MET10 | MET28 | YFR030W | YIR017C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism. | 0.698 |
MET10 | MET3 | YFR030W | YJR010W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Sulfate adenylyltransferase; ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.992 |
MET10 | MET5 | YFR030W | YJR137C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.999 |
MET10 | MET8 | YFR030W | YBR213W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Siroheme biosynthesis protein MET8; Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. MET8 subfamily. | 0.864 |
MET10 | TUM1 | YFR030W | YOR251C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Thiosulfate sulfurtransferase TUM1; Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized. | 0.942 |
MET14 | MET1 | YKL001C | YKR069W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family. | 0.951 |
MET14 | MET10 | YKL001C | YFR030W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | 0.994 |
MET14 | MET16 | YKL001C | YPR167C | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Phosphoadenosine phosphosulfate reductase; 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; Belongs to the PAPS reductase family. CysH subfamily. | 0.999 |