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OPT2 protein (Saccharomyces cerevisiae) - STRING interaction network
"OPT2" - Oligopeptide transporter in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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OPT2Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; Transports tetra- and pentapeptides. Does not transport glutathione (877 aa)    
Predicted Functional Partners:
YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters (725 aa)
           
  0.697
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p; Uptake of small peptides (601 aa)
     
 
  0.579
YPR195C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (109 aa)
     
   
  0.573
YPR197C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (187 aa)
           
  0.541
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; Probable DNA-binding protein which plays a role in protecting yeast cells against copper toxicity. May regulate the expression of important copper homeostatic genes (306 aa)
           
  0.520
YDL180W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole (547 aa)
           
  0.487
OXP1
5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (1286 aa)
           
  0.461
JLP1
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; Acts as a alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate (412 aa)
     
   
  0.457
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p; Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis (628 aa)
       
 
  0.440
STB5
Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; Binds to SIN3 (743 aa)
       
 
  0.424
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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