node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARR1 | ARR2 | YPR199C | YPR200C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | 0.946 |
ARR1 | ARR3 | YPR199C | YPR201W | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family. | 0.943 |
ARR1 | CAD1 | YPR199C | YDR423C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication. | 0.697 |
ARR1 | CIN5 | YPR199C | YOR028C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication. | 0.604 |
ARR1 | MED2 | YPR199C | YDL005C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia. | 0.725 |
ARR1 | RPN4 | YPR199C | YDL020C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Protein RPN4; Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress. | 0.609 |
ARR1 | YAP1 | YPR199C | YML007W | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication. | 0.943 |
ARR1 | YAP6 | YPR199C | YDR259C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication. | 0.698 |
ARR1 | YCF1 | YPR199C | YDR135C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Metal resistance protein YCF1; Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.806 |
ARR1 | YPR195C | YPR199C | YPR195C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | Uncharacterized protein YPR195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.605 |
ARR2 | ARR1 | YPR200C | YPR199C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | 0.946 |
ARR2 | ARR3 | YPR200C | YPR201W | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family. | 0.967 |
ARR2 | MED2 | YPR200C | YDL005C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia. | 0.477 |
ARR2 | YAP1 | YPR200C | YML007W | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication. | 0.515 |
ARR2 | YAP6 | YPR200C | YDR259C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication. | 0.451 |
ARR2 | YCF1 | YPR200C | YDR135C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Metal resistance protein YCF1; Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.835 |
ARR2 | YPR195C | YPR200C | YPR195C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | Uncharacterized protein YPR195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.470 |
ARR3 | ARR1 | YPR201W | YPR199C | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family. | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8. | 0.943 |
ARR3 | ARR2 | YPR201W | YPR200C | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family. | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. | 0.967 |
ARR3 | YAP1 | YPR201W | YML007W | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family. | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication. | 0.547 |