ARR3 protein (Saccharomyces cerevisiae) - STRING interaction network
"ARR3" - Plasma membrane metalloid/H+ antiporter in Saccharomyces cerevisiae
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Predicted Interactions
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Gene Fusion
ARR3Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Plasma membrane transporter that confers resistance to toxic metalloids by mediating extrusion of arsenite (As(III)) and antimonite (Sb(III)) out of cells. Displays low-affinity As(III)/H(+) and Sb(III)/H(+) exchange activity (404 aa)    
Predicted Functional Partners:
Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p; Involved in resistance to arsenic compounds (130 aa)
Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; /.../r to human cystic fibrosis protein CFTR; Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates (1515 aa)
Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds; Transcription activator of genes coding for transmembrane transporters (ACR2 and ACR3) involved in resistance to arsenic oxide. Its transcription activity is greatly induced by arsenite in a dose-dependent manner (294 aa)
Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p an /.../p; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes. Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, [...] (435 aa)
Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress; Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation- under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions (669 aa)
Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium; Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX [...] (650 aa)
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury (678 aa)
Putative maltose activator; May regulate the transcription of maltase and maltose permease genes (470 aa)
Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; Maintains high levels of reduced glutathione in the cytosol (483 aa)
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (111 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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