STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YPR204WDNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1. (1032 aa)    
Predicted Functional Partners:
YPR203W
Putative protein of unknown function; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
 
 
  
 0.895
YPR202W
Putative protein of unknown function; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo.
 
    
 0.893
YPR204C-A
Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.
      
 0.893
ESL1
hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication.
   
  
 0.764
YCR108C
Uncharacterized protein YCR108C; Putative protein of unknown function; identified by fungal homology and RT-PCR.
      
 0.693
YER190C-B
UPF0479 membrane protein YEL077W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.
      
 0.635
YOL166W-A
UPF0320 protein YOL166W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0320 family.
      
 0.559
YFL068W
UPF0479 membrane protein YFL068W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol.
      
 0.538
YLR046C
Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication.
   
 
 0.519
TIF2
Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication.
    
 
0.493
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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