close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvYLysR family transcriptional regulator, positive regulator for ilvC; Belongs to the LysR transcriptional regulatory family. (284 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
     0.728
GARC_3325
Hypothetical protein; Belongs to the LysR transcriptional regulatory family.
  
     0.617
GARC_3372
Hypothetical protein; Belongs to the LysR transcriptional regulatory family.
  
     0.591
estR
HTH-type transcriptional regulator estR; Belongs to the LysR transcriptional regulatory family.
  
     0.585
GARC_2685
LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.556
GARC_0860
Hypothetical protein; Belongs to the LysR transcriptional regulatory family.
  
     0.515
GARC_1243
Hypothetical protein; Belongs to the LysR transcriptional regulatory family.
  
     0.469
GARC_1009
Hypothetical protein.
       0.454
ygiM
SH3 domain protein.
  
     0.404
Your Current Organism:
Paraglaciecola arctica
NCBI taxonomy Id: 493475
Other names: Glaciecola arctica BSs20135, Glaciecola arctica str. BSs20135, Glaciecola arctica strain BSs20135, Glaciecola sp. BSs20135, P. arctica BSs20135, Paraglaciecola arctica BSs20135
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.