node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCM4 | MCM5 | A0A1J6J8E4 | A0A1J6I9H6 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM4 | MCM6 | A0A1J6J8E4 | A0A1J6J9D0 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM4 | MCM7 | A0A1J6J8E4 | A0A314KP27 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
MCM4 | ORC1A | A0A1J6J8E4 | A0A1J6K3S7 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
MCM4 | ORC2_0 | A0A1J6J8E4 | A0A314KGF4 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 2. | 0.984 |
MCM4 | ORC2_1 | A0A1J6J8E4 | A0A314LAR2 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 2. | 0.984 |
MCM4 | ORC4_0 | A0A1J6J8E4 | A0A1J6KQE3 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.983 |
MCM4 | ORC4_1 | A0A1J6J8E4 | A0A1J6IPK5 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 4. | 0.983 |
MCM4 | ORC5 | A0A1J6J8E4 | A0A1J6IR56 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 5. | 0.996 |
MCM4 | OSI_0 | A0A1J6J8E4 | A0A1J6KNS7 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 6. | 0.986 |
MCM5 | MCM4 | A0A1J6I9H6 | A0A1J6J8E4 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM5 | MCM6 | A0A1J6I9H6 | A0A1J6J9D0 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM5 | MCM7 | A0A1J6I9H6 | A0A314KP27 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
MCM5 | ORC1A | A0A1J6I9H6 | A0A1J6K3S7 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
MCM5 | ORC2_0 | A0A1J6I9H6 | A0A314KGF4 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 2. | 0.994 |
MCM5 | ORC2_1 | A0A1J6I9H6 | A0A314LAR2 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 2. | 0.994 |
MCM5 | ORC4_0 | A0A1J6I9H6 | A0A1J6KQE3 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.962 |
MCM5 | ORC4_1 | A0A1J6I9H6 | A0A1J6IPK5 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 4. | 0.962 |
MCM5 | ORC5 | A0A1J6I9H6 | A0A1J6IR56 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 5. | 0.997 |
MCM5 | OSI_0 | A0A1J6I9H6 | A0A1J6KNS7 | DNA helicase; Belongs to the MCM family. | Origin of replication complex subunit 6. | 0.965 |