STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIM8pH-response regulator protein palF/RIM8; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. (881 aa)    
Predicted Functional Partners:
RIM101
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes, thereby regulating the synthesis and secretion of alkaline protease XPR2 and acidic protease AXP1 depending on ambient pH. Specifically recognizes and binds the consensus sequence 5'-GCCARG- 3'. Required for mating and sporulation; Belongs to the pacC/RIM101 family.
    
 
 0.944
RIM9
pH-response regulator protein palI/RIM9; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Belongs to the palI/RIM9 family.
    
 
 0.930
RIM13
Calpain-like protease palB/RIM13; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
    
 
 0.928
RIM20
pH-response regulator protein RIM20; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity); Belongs to the palA/RIM20 family.
    
 
 0.919
RIM21
pH-response regulator protein palH/RIM21; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Belongs to the palH/RIM21 family.
    
 
 0.880
SNF7
Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
      
 0.850
BRO1
Vacuolar protein-sorting protein BRO1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family.
    
 
 0.759
VPS27
Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
      
 0.741
YALI0_E23859g
Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
      
 0.658
YALI0_C08473g
YALI0C08473p.
      
 0.633
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.