STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PALC_YARLIpH-response regulator protein palC; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. (441 aa)    
Predicted Functional Partners:
SNF7
Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
    
 0.866
RIM101
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes, thereby regulating the synthesis and secretion of alkaline protease XPR2 and acidic protease AXP1 depending on ambient pH. Specifically recognizes and binds the consensus sequence 5'-GCCARG- 3'. Required for mating and sporulation; Belongs to the pacC/RIM101 family.
    
 
 0.559
RIM8
pH-response regulator protein palF/RIM8; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
    
 
 0.551
RIM13
Calpain-like protease palB/RIM13; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
    
 
 0.542
YALI0_E18986g
YALI0E18986p.
   
 
 0.540
YALI0_B08294g
YALI0B08294p.
    
 0.496
YALI0_F19272g
YALI0F19272p.
    
 0.413
BRO1
Vacuolar protein-sorting protein BRO1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family.
      
 0.412
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122
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