node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dmdA_1 | dmdA_2 | MBCUR_04790 | MBCUR_06970 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.514 |
dmdA_1 | dmdB_2 | MBCUR_04790 | MBCUR_13350 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.999 |
dmdA_1 | hicd_1 | MBCUR_04790 | MBCUR_06950 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Homoisocitrate dehydrogenase. | 0.980 |
dmdA_1 | hicd_2 | MBCUR_04790 | MBCUR_07350 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Homoisocitrate dehydrogenase. | 0.998 |
dmdA_1 | ilvC | MBCUR_04790 | MBCUR_01910 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.884 |
dmdA_1 | ilvH | MBCUR_04790 | MBCUR_10370 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Acetolactate synthase small subunit. | 0.825 |
dmdA_1 | leuA_1 | MBCUR_04790 | MBCUR_04800 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.999 |
dmdA_1 | leuA_2 | MBCUR_04790 | MBCUR_10310 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.876 |
dmdA_1 | leuA_3 | MBCUR_04790 | MBCUR_14610 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.856 |
dmdA_1 | thrC | MBCUR_04790 | MBCUR_07530 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.405 |
dmdA_2 | dmdA_1 | MBCUR_06970 | MBCUR_04790 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.514 |
dmdA_2 | dmdB_2 | MBCUR_06970 | MBCUR_13350 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.997 |
dmdA_2 | hicd_1 | MBCUR_06970 | MBCUR_06950 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Homoisocitrate dehydrogenase. | 0.999 |
dmdA_2 | hicd_2 | MBCUR_06970 | MBCUR_07350 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Homoisocitrate dehydrogenase. | 0.973 |
dmdA_2 | ilvC | MBCUR_06970 | MBCUR_01910 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.884 |
dmdA_2 | ilvH | MBCUR_06970 | MBCUR_10370 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Acetolactate synthase small subunit. | 0.825 |
dmdA_2 | leuA_1 | MBCUR_06970 | MBCUR_04800 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.724 |
dmdA_2 | leuA_2 | MBCUR_06970 | MBCUR_10310 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.997 |
dmdA_2 | leuA_3 | MBCUR_06970 | MBCUR_14610 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.995 |
dmdA_2 | thrC | MBCUR_06970 | MBCUR_07530 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.405 |