STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
LEU23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (362 aa)    
Predicted Functional Partners:
C5E063_ZYGRC
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.995
C5E4D3_ZYGRC
ZYRO0E04994p.
  
 0.975
C5E1C8_ZYGRC
Acetolactate synthase.
  
 0.969
C5DQT2_ZYGRC
Threonine dehydratase.
  
 
 0.919
C5DYU2_ZYGRC
ZYRO0F15774p.
  
 
 0.919
C5DZ64_ZYGRC
ZYRO0F18524p.
  
 
 0.919
C5DQB1_ZYGRC
Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
 
 0.854
C5E048_ZYGRC
Tryptophan synthase.
  
  
 0.794
C5DTG7_ZYGRC
ZYRO0C08404p; In the N-terminal section; belongs to the acetylglutamate kinase family.
  
  
 0.747
C5DZ21_ZYGRC
Histidine biosynthesis trifunctional protein.
  
  
 0.732
Your Current Organism:
Zygosaccharomyces rouxii
NCBI taxonomy Id: 559307
Other names: Z. rouxii CBS 732, Zygosaccharomyces rouxii CBS 732
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