B9J08_003714 protein (Candida auris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

B9J08_003714

Uncharacterized protein. (461 aa)

Predicted Functional Partners:

B9J08_002874

0.974

B9J08_001925

0.939

B9J08_002986

0.706

B9J08_004596

0.680

B9J08_002477

0.607

B9J08_002117

0.601

B9J08_004221

0.585

B9J08_001244

0.585

B9J08_002600

0.552

B9J08_005581

0.548

Your Current Organism:

Candida auris

NCBI taxonomy Id: 498019
Other names: B11220, CBS 10913, CBS10913, CDC B11220, Candida auris Satoh & Makimura, 2009, Candida sp. KM-143, DSM 21092, JCM 15448, JCM15448, [. auris, [Candida] auris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9J08_001244	B9J08_001925	A0A2H1A1D8	A0A2H0ZYW5	Uncharacterized protein.	Uncharacterized protein.	0.585
B9J08_001244	B9J08_002874	A0A2H1A1D8	A0A2H0ZKY6	Uncharacterized protein.	Uncharacterized protein.	0.585
B9J08_001244	B9J08_003714	A0A2H1A1D8	A0A2H0ZP72	Uncharacterized protein.	Uncharacterized protein.	0.585
B9J08_001925	B9J08_001244	A0A2H0ZYW5	A0A2H1A1D8	Uncharacterized protein.	Uncharacterized protein.	0.585
B9J08_001925	B9J08_002477	A0A2H0ZYW5	A0A2H0ZYD7	Uncharacterized protein.	Uncharacterized protein; Belongs to the phosphohexose mutase family.	0.607
B9J08_001925	B9J08_002600	A0A2H0ZYW5	A0A2H0ZK23	Uncharacterized protein.	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	0.646
B9J08_001925	B9J08_002874	A0A2H0ZYW5	A0A2H0ZKY6	Uncharacterized protein.	Uncharacterized protein.	0.642
B9J08_001925	B9J08_002986	A0A2H0ZYW5	A0A2H0ZL93	Uncharacterized protein.	1,4-alpha-glucan-branching enzyme.	0.706
B9J08_001925	B9J08_003714	A0A2H0ZYW5	A0A2H0ZP72	Uncharacterized protein.	Uncharacterized protein.	0.939
B9J08_001925	B9J08_004221	A0A2H0ZYW5	A0A2H0ZJB8	Uncharacterized protein.	Uncharacterized protein.	0.681
B9J08_001925	B9J08_005581	A0A2H0ZYW5	A0A2H0ZBV2	Uncharacterized protein.	Glycogen debranching enzyme.	0.548
B9J08_002117	B9J08_003714	A0A2H0ZWH7	A0A2H0ZP72	Argininosuccinate lyase.	Uncharacterized protein.	0.601
B9J08_002477	B9J08_001925	A0A2H0ZYD7	A0A2H0ZYW5	Uncharacterized protein; Belongs to the phosphohexose mutase family.	Uncharacterized protein.	0.607
B9J08_002477	B9J08_002874	A0A2H0ZYD7	A0A2H0ZKY6	Uncharacterized protein; Belongs to the phosphohexose mutase family.	Uncharacterized protein.	0.607
B9J08_002477	B9J08_002986	A0A2H0ZYD7	A0A2H0ZL93	Uncharacterized protein; Belongs to the phosphohexose mutase family.	1,4-alpha-glucan-branching enzyme.	0.936
B9J08_002477	B9J08_003714	A0A2H0ZYD7	A0A2H0ZP72	Uncharacterized protein; Belongs to the phosphohexose mutase family.	Uncharacterized protein.	0.607
B9J08_002477	B9J08_005581	A0A2H0ZYD7	A0A2H0ZBV2	Uncharacterized protein; Belongs to the phosphohexose mutase family.	Glycogen debranching enzyme.	0.972
B9J08_002600	B9J08_001925	A0A2H0ZK23	A0A2H0ZYW5	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Uncharacterized protein.	0.646
B9J08_002600	B9J08_002874	A0A2H0ZK23	A0A2H0ZKY6	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Uncharacterized protein.	0.645
B9J08_002600	B9J08_003714	A0A2H0ZK23	A0A2H0ZP72	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Uncharacterized protein.	0.552

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.826

expected number of edges:

20

PPI enrichment p-value:

0.487

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006189

De novo IMP biosynthetic process

8 of 11

2.29

6.26

1.45e-14

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

9 of 19

2.1

5.74

9.46e-15

GO:0006164

Purine nucleotide biosynthetic process

10 of 45

1.77

4.4

9.46e-15

GO:0009152

Purine ribonucleotide biosynthetic process

9 of 43

1.75

4.02

3.31e-13

GO:0009113

Purine nucleobase biosynthetic process

2 of 3

2.25

1.36

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 35

1.48

1.03

0.0051

GO:0003937

IMP cyclohydrolase activity

2 of 2

2.43

0.89

0.0236

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 5

2.03

0.74

0.0410

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1059

De novo IMP biosynthetic process, and One-carbon metabolism

9 of 20

2.08

5.68

7.94e-15

CL:1063

De novo IMP biosynthetic process

7 of 10

2.27

5.4

2.21e-12

CL:1015

Mixed, incl. Purine nucleoside monophosphate biosynthetic process, and Folic acid-containing compound metabolic process

10 of 42

1.8

4.55

7.94e-15

CL:1066

De novo IMP biosynthetic process

5 of 5

2.43

4.14

6.87e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

10 of 82

1.51

3.05

6.34e-13

map01110

Biosynthesis of secondary metabolites

10 of 343

0.89

0.97

2.93e-07

map01100

Metabolic pathways

10 of 906

0.47

0.37

0.0024

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 665

0.56

0.39

0.0137

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

7 of 13

2.16

4.86

1.33e-11

KW-0436

Ligase

4 of 67

1.2

0.8

0.0089

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