B9J08_001939 protein (Candida auris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

B9J08_001939

Uncharacterized protein. (819 aa)

Predicted Functional Partners:

B9J08_003382

0.876

B9J08_003795

0.869

B9J08_004851

0.829

B9J08_005373

0.818

B9J08_002348

0.809

B9J08_004219

0.803

B9J08_000910

0.770

B9J08_000934

0.767

ERB1

0.763

YTM1

0.743

Your Current Organism:

Candida auris

NCBI taxonomy Id: 498019
Other names: B11220, CBS 10913, CBS10913, CDC B11220, Candida auris Satoh & Makimura, 2009, Candida sp. KM-143, DSM 21092, JCM 15448, JCM15448, [. auris, [Candida] auris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9J08_000910	B9J08_000934	A0A2H1A741	A0A2H1A4T5	Uncharacterized protein.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.997
B9J08_000910	B9J08_001939	A0A2H1A741	A0A2H1A091	Uncharacterized protein.	Uncharacterized protein.	0.770
B9J08_000910	B9J08_002348	A0A2H1A741	A0A2H0ZW63	Uncharacterized protein.	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family.	0.991
B9J08_000910	B9J08_003382	A0A2H1A741	A0A2H0ZNA4	Uncharacterized protein.	Uncharacterized protein.	0.890
B9J08_000910	B9J08_003795	A0A2H1A741	A0A2H0ZPD4	Uncharacterized protein.	ATP-dependent RNA helicase DOB1.	0.731
B9J08_000910	B9J08_004219	A0A2H1A741	A0A2H0ZIB1	Uncharacterized protein.	Uncharacterized protein.	0.949
B9J08_000910	B9J08_004851	A0A2H1A741	A0A2H0ZGS8	Uncharacterized protein.	MI domain-containing protein.	0.461
B9J08_000910	B9J08_005373	A0A2H1A741	A0A2H0ZEG3	Uncharacterized protein.	ATP-dependent RNA helicase DBP9.	0.868
B9J08_000910	ERB1	A0A2H1A741	A0A2H0ZEH4	Uncharacterized protein.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
B9J08_000910	YTM1	A0A2H1A741	A0A2H0ZF86	Uncharacterized protein.	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.990
B9J08_000934	B9J08_000910	A0A2H1A4T5	A0A2H1A741	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.997
B9J08_000934	B9J08_001939	A0A2H1A4T5	A0A2H1A091	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.767
B9J08_000934	B9J08_002348	A0A2H1A4T5	A0A2H0ZW63	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family.	0.929
B9J08_000934	B9J08_003382	A0A2H1A4T5	A0A2H0ZNA4	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.876
B9J08_000934	B9J08_003795	A0A2H1A4T5	A0A2H0ZPD4	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	ATP-dependent RNA helicase DOB1.	0.812
B9J08_000934	B9J08_004219	A0A2H1A4T5	A0A2H0ZIB1	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.904
B9J08_000934	B9J08_004851	A0A2H1A4T5	A0A2H0ZGS8	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	MI domain-containing protein.	0.412
B9J08_000934	B9J08_005373	A0A2H1A4T5	A0A2H0ZEG3	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	ATP-dependent RNA helicase DBP9.	0.869
B9J08_000934	ERB1	A0A2H1A4T5	A0A2H0ZEH4	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.977
B9J08_000934	YTM1	A0A2H1A4T5	A0A2H0ZF86	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.950

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.871

expected number of edges:

12

PPI enrichment p-value:

6.15e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051754

Meiotic sister chromatid cohesion, centromeric

4 of 6

3.29

4.5

6.75e-09

GO:0007094

Mitotic spindle assembly checkpoint signaling

4 of 12

2.99

4.19

1.95e-08

GO:0019220

Regulation of phosphate metabolic process

5 of 212

1.84

2.68

6.04e-07

GO:0006470

Protein dephosphorylation

4 of 192

1.78

2.02

3.25e-05

GO:0007165

Signal transduction

5 of 1728

0.93

0.64

0.0088

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 85

2.23

3.37

1.49e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000159

Protein phosphatase type 2A complex

5 of 34

2.63

4.76

7.62e-10

GO:0000776

Kinetochore

4 of 26

2.65

3.96

3.33e-08

GO:0010369

Chromocenter

2 of 4

3.16

2.15

0.00013

GO:0005828

Kinetochore microtubule

2 of 4

3.16

2.15

0.00013

GO:0005829

Cytosol

5 of 2313

0.8

0.48

0.0269

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6644

Cyclin A/B1/B2 associated events during G2/M transition, and Protein phosphatase 2A, regulatory B subunit, B56

7 of 38

2.73

7.18

1.12e-14

CL:6645

Cyclin A/B1/B2 associated events during G2/M transition, and Protein phosphatase 2A, regulatory B subunit, B56

4 of 30

2.59

3.56

1.81e-07

CL:6704

CTLA4 inhibitory signaling, and Protein phosphatase 2A regulatory subunit PR55

3 of 8

3.04

3.09

2.35e-06

CL:19076

Inactivation of APC/C via direct inhibition of the APC/C complex, and Mad3/Bub1 homology region 1

3 of 28

2.5

2.31

4.68e-05

CL:19057

Anaphase-promoting complex-dependent catabolic process, and Cell cycle phase transition

4 of 108

2.03

2.3

1.99e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

6 of 296

1.77

2.92

4.38e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 32

2.74

6.55

2.36e-13

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

6 of 33

2.72

6.54

2.36e-13

MAP-5673000

RAF activation

6 of 34

2.71

6.52

2.36e-13

MAP-388841

Costimulation by the CD28 family

6 of 36

2.69

6.49

2.36e-13

MAP-450282

MAPK targets/ Nuclear events mediated by MAP kinases

5 of 20

2.86

5.96

6.09e-12

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990706

MAD1 complex

4 of 4

3.47

5.06

7.01e-10

GOCC:0000779

Condensed chromosome, centromeric region

4 of 22

2.72

3.81

7.46e-08

GOCC:0000159

Protein phosphatase type 2A complex

4 of 23

2.71

3.8

7.46e-08

GOCC:0000776

Kinetochore

4 of 26

2.65

3.78

7.46e-08

GOCC:1990728

Mitotic spindle assembly checkpoint MAD1-MAD2 complex

2 of 2

3.47

2.26

8.61e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13646

HEAT repeats

3 of 7

3.1

2.82

7.56e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013212

Mad3/Bub1 homology region 1

4 of 4

3.47

4.69

3.25e-09

IPR021133

HEAT, type 2

4 of 23

2.71

3.43

4.06e-07

IPR015661

Mitotic spindle checkpoint protein Bub1/Mad3

3 of 3

3.47

3.27

1.24e-06

IPR011989

Armadillo-like helical

5 of 336

1.64

1.73

8.96e-05

IPR016024

Armadillo-type fold

5 of 411

1.55

0.00019

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

3.47

1.94

0.00033

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