B9J08_001260 protein (Candida auris) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

B9J08_001260

Uncharacterized protein. (823 aa)

Predicted Functional Partners:

B9J08_001108

0.837

B9J08_003586

0.830

B9J08_001616

0.790

B9J08_005376

0.668

B9J08_005259

0.660

B9J08_003463

0.643

B9J08_000514

0.639

B9J08_002303

0.626

B9J08_003855

0.587

B9J08_005241

0.573

Your Current Organism:

Candida auris

NCBI taxonomy Id: 498019
Other names: B11220, CBS 10913, CBS10913, CDC B11220, Candida auris Satoh & Makimura, 2009, Candida sp. KM-143, DSM 21092, JCM 15448, JCM15448, [. auris, [Candida] auris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9J08_000514	B9J08_001108	A0A2H1A555	A0A2H1A0X6	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.994
B9J08_000514	B9J08_001260	A0A2H1A555	A0A2H1A1G6	Uncharacterized protein.	Uncharacterized protein.	0.639
B9J08_000514	B9J08_003586	A0A2H1A555	A0A2H0ZMV9	Uncharacterized protein.	Uncharacterized protein.	0.960
B9J08_000514	B9J08_003855	A0A2H1A555	A0A2H0ZNP0	Uncharacterized protein.	Uncharacterized protein.	0.549
B9J08_000514	B9J08_005241	A0A2H1A555	A0A2H0ZD41	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.426
B9J08_000514	B9J08_005259	A0A2H1A555	A0A2H0ZD64	Uncharacterized protein.	Ubiquitin-like protein SMT3.	0.891
B9J08_000514	B9J08_005376	A0A2H1A555	A0A2H0ZDH5	Uncharacterized protein.	DNA repair protein rad18.	0.820
B9J08_001108	B9J08_000514	A0A2H1A0X6	A0A2H1A555	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.994
B9J08_001108	B9J08_001260	A0A2H1A0X6	A0A2H1A1G6	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.837
B9J08_001108	B9J08_002303	A0A2H1A0X6	A0A2H0ZY71	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Protein ARG5,6, mitochondrial; In the N-terminal section; belongs to the acetylglutamate kinase family.	0.756
B9J08_001108	B9J08_003463	A0A2H1A0X6	A0A2H0ZMK5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Histidine biosynthesis trifunctional protein.	0.666
B9J08_001108	B9J08_003586	A0A2H1A0X6	A0A2H0ZMV9	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.993
B9J08_001108	B9J08_003855	A0A2H1A0X6	A0A2H0ZNP0	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.770
B9J08_001108	B9J08_005241	A0A2H1A0X6	A0A2H0ZD41	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.808
B9J08_001108	B9J08_005259	A0A2H1A0X6	A0A2H0ZD64	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Ubiquitin-like protein SMT3.	0.779
B9J08_001108	B9J08_005376	A0A2H1A0X6	A0A2H0ZDH5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DNA repair protein rad18.	0.917
B9J08_001260	B9J08_000514	A0A2H1A1G6	A0A2H1A555	Uncharacterized protein.	Uncharacterized protein.	0.639
B9J08_001260	B9J08_001108	A0A2H1A1G6	A0A2H1A0X6	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.837
B9J08_001260	B9J08_001616	A0A2H1A1G6	A0A2H0ZXY1	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.790
B9J08_001260	B9J08_002303	A0A2H1A1G6	A0A2H0ZY71	Uncharacterized protein.	Protein ARG5,6, mitochondrial; In the N-terminal section; belongs to the acetylglutamate kinase family.	0.626

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Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

3.6e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030834

Regulation of actin filament depolymerization

5 of 13

2.28

3.25

3.27e-07

GO:0030837

Negative regulation of actin filament polymerization

5 of 14

2.24

3.23

3.27e-07

GO:0051016

Barbed-end actin filament capping

4 of 10

2.29

2.93

1.74e-06

GO:0007010

Cytoskeleton organization

7 of 140

1.39

1.89

6.31e-07

GO:0030036

Actin cytoskeleton organization

5 of 76

1.51

1.72

3.18e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051015

Actin filament binding

6 of 24

2.09

3.68

1.01e-08

GO:0044877

Protein-containing complex binding

7 of 145

1.38

1.8

1.57e-06

GO:0005200

Structural constituent of cytoskeleton

3 of 10

2.17

1.73

0.00047

GO:0005515

Protein binding

7 of 607

0.75

0.51

0.0112

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

10 of 59

1.92

5.33

4.84e-16

GO:0005869

Dynactin complex

4 of 4

2.69

3.62

1.67e-07

GO:0005856

Cytoskeleton

11 of 171

1.5

3.16

1.77e-14

GO:0008290

F-actin capping protein complex

3 of 3

2.69

2.73

8.80e-06

GO:0030479

Actin cortical patch

5 of 37

1.82

2.55

1.27e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30323040

(2019) A Novel Actin Binding Drug with In Vivo Efficacy.

2 of 2

2.69

1.14

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1450

Microtubule associated complex, and F-actin capping protein complex

7 of 11

2.5

6.12

4.14e-13

CL:1452

Dynactin complex, and Actin capping

5 of 5

2.69

4.72

1.07e-09

CL:2177

Actin cortical patch, and Actin polymerization or depolymerization

3 of 28

1.72

1.16

0.0042

CL:2198

Actin filament depolymerization, and Calponin homology domain

2 of 6

2.21

1.0

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-109582

Hemostasis

5 of 80

1.49

1.42

0.00032

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 32

1.66

0.87

0.0174

MAP-6807878

COPI-mediated anterograde transport

3 of 43

1.54

0.76

0.0266

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015629

Actin cytoskeleton

8 of 50

1.9

4.24

7.60e-12

GOCC:0005856

Cytoskeleton

10 of 134

1.56

3.22

1.25e-12

GOCC:0005875

Microtubule associated complex

4 of 13

2.18

2.6

6.51e-06

GOCC:0008290

F-actin capping protein complex

3 of 3

2.69

2.56

1.87e-05

GOCC:0005869

Dynactin complex

3 of 3

2.69

2.56

1.87e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 12

2.09

1.65

0.00061

KW-0117

Actin capping

2 of 2

2.69

1.43

0.0025

KW-0206

Cytoskeleton

2 of 14

1.85

0.78

0.0325

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042276

F-actin-capping protein subunit alpha/beta, domain 2

2 of 2

2.69

0.72

0.0496

IPR037282

F-actin-capping protein subunit alpha/beta

2 of 2

2.69

0.72

0.0496

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