node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA74291.1 | SFA76307.1 | SAMN05660845_0328 | SAMN05660845_0423 | Molecular chaperone HtpG. | DnaJ domain-containing protein. | 0.952 |
SFA74291.1 | SFA92824.1 | SAMN05660845_0328 | SAMN05660845_1026 | Molecular chaperone HtpG. | Curved DNA-binding protein. | 0.952 |
SFA74291.1 | clpB | SAMN05660845_0328 | SAMN05660845_0070 | Molecular chaperone HtpG. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.712 |
SFA74291.1 | clpP | SAMN05660845_0328 | SAMN05660845_0516 | Molecular chaperone HtpG. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.493 |
SFA74291.1 | dnaJ | SAMN05660845_0328 | SAMN05660845_0248 | Molecular chaperone HtpG. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.952 |
SFA74291.1 | dnaK | SAMN05660845_0328 | SAMN05660845_2341 | Molecular chaperone HtpG. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
SFA74291.1 | groS | SAMN05660845_0328 | SAMN05660845_0444 | Molecular chaperone HtpG. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.824 |
SFA74291.1 | grpE | SAMN05660845_0328 | SAMN05660845_0249 | Molecular chaperone HtpG. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.797 |
SFA74291.1 | lon | SAMN05660845_0328 | SAMN05660845_0026 | Molecular chaperone HtpG. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.735 |
SFA76307.1 | SFA74291.1 | SAMN05660845_0423 | SAMN05660845_0328 | DnaJ domain-containing protein. | Molecular chaperone HtpG. | 0.952 |
SFA76307.1 | clpB | SAMN05660845_0423 | SAMN05660845_0070 | DnaJ domain-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.724 |
SFA76307.1 | clpP | SAMN05660845_0423 | SAMN05660845_0516 | DnaJ domain-containing protein. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.516 |
SFA76307.1 | dnaK | SAMN05660845_0423 | SAMN05660845_2341 | DnaJ domain-containing protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.976 |
SFA76307.1 | groS | SAMN05660845_0423 | SAMN05660845_0444 | DnaJ domain-containing protein. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.589 |
SFA76307.1 | grpE | SAMN05660845_0423 | SAMN05660845_0249 | DnaJ domain-containing protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.845 |
SFA76307.1 | lon | SAMN05660845_0423 | SAMN05660845_0026 | DnaJ domain-containing protein. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.576 |
SFA86425.1 | clpB | SAMN05660845_0695 | SAMN05660845_0070 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.860 |
SFA86425.1 | clpP | SAMN05660845_0695 | SAMN05660845_0516 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.730 |
SFA92824.1 | SFA74291.1 | SAMN05660845_1026 | SAMN05660845_0328 | Curved DNA-binding protein. | Molecular chaperone HtpG. | 0.952 |
SFA92824.1 | clpB | SAMN05660845_1026 | SAMN05660845_0070 | Curved DNA-binding protein. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.724 |