node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA71030.1 | hemE | SAMN05660845_0164 | SAMN05660845_1151 | Radical SAM superfamily enzyme YgiQ, UPF0313 family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.866 |
SFA98305.1 | SFA98321.1 | SAMN05660845_1147 | SAMN05660845_1148 | Porphobilinogen synthase; Belongs to the ALAD family. | Coproporphyrinogen oxidase. | 0.835 |
SFA98305.1 | SFA98409.1 | SAMN05660845_1147 | SAMN05660845_1152 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase. | 0.945 |
SFA98305.1 | SFB03791.1 | SAMN05660845_1147 | SAMN05660845_1455 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.920 |
SFA98305.1 | SFB12072.1 | SAMN05660845_1147 | SAMN05660845_1732 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase. | 0.853 |
SFA98305.1 | hemA | SAMN05660845_1147 | SAMN05660845_1154 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.936 |
SFA98305.1 | hemC | SAMN05660845_1147 | SAMN05660845_1153 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
SFA98305.1 | hemE | SAMN05660845_1147 | SAMN05660845_1151 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.911 |
SFA98305.1 | hemH | SAMN05660845_1147 | SAMN05660845_1159 | Porphobilinogen synthase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.444 |
SFA98321.1 | SFA98305.1 | SAMN05660845_1148 | SAMN05660845_1147 | Coproporphyrinogen oxidase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.835 |
SFA98321.1 | SFA98409.1 | SAMN05660845_1148 | SAMN05660845_1152 | Coproporphyrinogen oxidase. | uroporphyrinogen-III synthase. | 0.713 |
SFA98321.1 | SFB12718.1 | SAMN05660845_1148 | SAMN05660845_1767 | Coproporphyrinogen oxidase. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.932 |
SFA98321.1 | hemA | SAMN05660845_1148 | SAMN05660845_1154 | Coproporphyrinogen oxidase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.769 |
SFA98321.1 | hemC | SAMN05660845_1148 | SAMN05660845_1153 | Coproporphyrinogen oxidase. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.786 |
SFA98321.1 | hemE | SAMN05660845_1148 | SAMN05660845_1151 | Coproporphyrinogen oxidase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.993 |
SFA98321.1 | hemH | SAMN05660845_1148 | SAMN05660845_1159 | Coproporphyrinogen oxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.689 |
SFA98409.1 | SFA98305.1 | SAMN05660845_1152 | SAMN05660845_1147 | uroporphyrinogen-III synthase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.945 |
SFA98409.1 | SFA98321.1 | SAMN05660845_1152 | SAMN05660845_1148 | uroporphyrinogen-III synthase. | Coproporphyrinogen oxidase. | 0.713 |
SFA98409.1 | SFB03791.1 | SAMN05660845_1152 | SAMN05660845_1455 | uroporphyrinogen-III synthase. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.916 |
SFA98409.1 | SFB12718.1 | SAMN05660845_1152 | SAMN05660845_1767 | uroporphyrinogen-III synthase. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.505 |