node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA84308.1 | SFB03404.1 | SAMN05660845_0585 | SAMN05660845_1429 | Dihydrofolate synthase / folylpolyglutamate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.908 |
SFA84308.1 | SFB03421.1 | SAMN05660845_0585 | SAMN05660845_1430 | Dihydrofolate synthase / folylpolyglutamate synthase. | 2TM domain-containing protein. | 0.682 |
SFA84308.1 | SFB04000.1 | SAMN05660845_0585 | SAMN05660845_1468 | Dihydrofolate synthase / folylpolyglutamate synthase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.434 |
SFA84308.1 | gcvT | SAMN05660845_0585 | SAMN05660845_2353 | Dihydrofolate synthase / folylpolyglutamate synthase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.637 |
SFA84308.1 | glyA | SAMN05660845_0585 | SAMN05660845_0625 | Dihydrofolate synthase / folylpolyglutamate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
SFA84308.1 | thyA | SAMN05660845_0585 | SAMN05660845_1432 | Dihydrofolate synthase / folylpolyglutamate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.927 |
SFB03404.1 | SFA84308.1 | SAMN05660845_1429 | SAMN05660845_0585 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase / folylpolyglutamate synthase. | 0.908 |
SFB03404.1 | SFB03421.1 | SAMN05660845_1429 | SAMN05660845_1430 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2TM domain-containing protein. | 0.925 |
SFB03404.1 | SFB19229.1 | SAMN05660845_1429 | SAMN05660845_1943 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine dehydrogenase; Belongs to the GcvP family. | 0.906 |
SFB03404.1 | gcvT | SAMN05660845_1429 | SAMN05660845_2353 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.907 |
SFB03404.1 | glyA | SAMN05660845_1429 | SAMN05660845_0625 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
SFB03404.1 | tdk | SAMN05660845_1429 | SAMN05660845_1057 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidine kinase. | 0.486 |
SFB03404.1 | thyA | SAMN05660845_1429 | SAMN05660845_1432 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
SFB03421.1 | SFA84308.1 | SAMN05660845_1430 | SAMN05660845_0585 | 2TM domain-containing protein. | Dihydrofolate synthase / folylpolyglutamate synthase. | 0.682 |
SFB03421.1 | SFB03404.1 | SAMN05660845_1430 | SAMN05660845_1429 | 2TM domain-containing protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.925 |
SFB03421.1 | SFB19229.1 | SAMN05660845_1430 | SAMN05660845_1943 | 2TM domain-containing protein. | Glycine dehydrogenase; Belongs to the GcvP family. | 0.715 |
SFB03421.1 | gcvT | SAMN05660845_1430 | SAMN05660845_2353 | 2TM domain-containing protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.682 |
SFB03421.1 | glyA | SAMN05660845_1430 | SAMN05660845_0625 | 2TM domain-containing protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.560 |
SFB03421.1 | tdk | SAMN05660845_1430 | SAMN05660845_1057 | 2TM domain-containing protein. | Thymidine kinase. | 0.486 |
SFB03421.1 | thyA | SAMN05660845_1430 | SAMN05660845_1432 | 2TM domain-containing protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.948 |