STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDSuccinyl-coa synthetase alpha chain 2; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)    
Predicted Functional Partners:
sucC
Succinyl-coa synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
sdhA
This HMM represents the succinate dehydrogenase flavoprotein subunit as found in the low-GC Gram-positive bacteria and a few other lineages. This enzyme may act in a complete or partial TCA cycle, or act in the opposite direction as fumarate reductase.
 0.996
sdhB
Succinate dehydrogenase/fumarate reductase iron-sulfur protein.
 
 0.995
sdhC
Succinate dehydrogenase (cytochrome b558 subunit).
  
 
 0.989
HM1_0377
Methymalonyl-coa mutase c-terminal domain protein; The conserved domain is under EC 5.4.99.2.
    
 0.967
HM1_1028
NADH dehydrogenase conserved domain protein, nuoe and nuof.
  
 
 0.958
HM1_0376
Methylmalonyl-coa mutase, n-terminal domain/subunit.
    
 0.952
HM1_0807
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Contains alpha, beta and gamma subunits of 2-oxoacid:ferredoxin oxidoreductase, a gene related to pyruvate:ferredoxin (flavodoxin) oxidoreductase. These genes have the gene symbols porA, porB, porG and napF.
  
 
 0.938
korA
2-oxoglutarate oxidoreductase, alpha subunit, putative.
 
 
 0.928
adhE
Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.927
Your Current Organism:
Heliobacterium modesticaldum
NCBI taxonomy Id: 498761
Other names: H. modesticaldum Ice1, Heliobacterium modesticaldum Ice1, Heliobacterium modesticaldum str. Ice1, Heliobacterium modesticaldum strain Ice1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.