STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HM1_2993Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)    
Predicted Functional Partners:
accC
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.947
HM1_0807
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Contains alpha, beta and gamma subunits of 2-oxoacid:ferredoxin oxidoreductase, a gene related to pyruvate:ferredoxin (flavodoxin) oxidoreductase. These genes have the gene symbols porA, porB, porG and napF.
  
 
 0.940
adhE
Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.938
HM1_0896
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.923
HM1_1519
2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.921
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.914
acsA
Acetyl-coenzyme a synthetase.
  
 
 0.913
nifV
Homocitrate synthase, nifv; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.906
oorA
2-oxoacid:ferredoxin oxidoreductase, alpha subunit, putative.
   
 
 0.902
HM1_0359
Ketoisovalerate oxidoreductase.
   
 
 0.902
Your Current Organism:
Heliobacterium modesticaldum
NCBI taxonomy Id: 498761
Other names: H. modesticaldum Ice1, Heliobacterium modesticaldum Ice1, Heliobacterium modesticaldum str. Ice1, Heliobacterium modesticaldum strain Ice1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.