| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TO73_0454 | TO73_0873 | TO73_0454 | TO73_0873 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | 0.917 |
| TO73_0454 | TO73_0877 | TO73_0454 | TO73_0877 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III synthase. | 0.900 |
| TO73_0454 | TO73_1007 | TO73_0454 | TO73_1007 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | 0.952 |
| TO73_0454 | TO73_1009 | TO73_0454 | TO73_1009 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Sirohydrochlorin cobaltochelatase / putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis. | 0.491 |
| TO73_0454 | hemC | TO73_0454 | TO73_2199 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.982 |
| TO73_0454 | hemE | TO73_0454 | TO73_1708 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.924 |
| TO73_0873 | TO73_0454 | TO73_0873 | TO73_0454 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.917 |
| TO73_0873 | TO73_0875 | TO73_0873 | TO73_0875 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Phosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.970 |
| TO73_0873 | TO73_0876 | TO73_0873 | TO73_0876 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Siroheme synthase / precorrin-2 oxidase / sirohydrochlorin ferrochelatase. | 0.999 |
| TO73_0873 | TO73_0877 | TO73_0873 | TO73_0877 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase. | 0.982 |
| TO73_0873 | TO73_0878 | TO73_0873 | TO73_0878 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Ferredoxin-sulfite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.969 |
| TO73_0873 | TO73_1007 | TO73_0873 | TO73_1007 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | 0.953 |
| TO73_0873 | TO73_1009 | TO73_0873 | TO73_1009 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Sirohydrochlorin cobaltochelatase / putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis. | 0.722 |
| TO73_0873 | TO73_1013 | TO73_0873 | TO73_1013 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.921 |
| TO73_0873 | hemC | TO73_0873 | TO73_2199 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.957 |
| TO73_0873 | hemE | TO73_0873 | TO73_1708 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |
| TO73_0875 | TO73_0873 | TO73_0875 | TO73_0873 | Phosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. | 0.970 |
| TO73_0875 | TO73_0876 | TO73_0875 | TO73_0876 | Phosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | Siroheme synthase / precorrin-2 oxidase / sirohydrochlorin ferrochelatase. | 0.940 |
| TO73_0875 | TO73_0877 | TO73_0875 | TO73_0877 | Phosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | uroporphyrinogen-III synthase. | 0.869 |
| TO73_0875 | TO73_0878 | TO73_0875 | TO73_0878 | Phosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | Ferredoxin-sulfite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.998 |