Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
KWV95998.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)    
Predicted Functional Partners:
KWV95999.1
Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
       0.769
KWV95451.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.640
KWV92449.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.638
KWV94941.1
Peptidase M28; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.636
hrcA
Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
       0.611
KWV92441.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.609
KWV94036.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.605
KWV92526.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.593
KWV96000.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.589
Your Current Organism:
Erythrobacter sp. AP23
NCBI taxonomy Id: 499656
Other names: E. sp. AP23
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