STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pc21g01150Pc21g01150 protein. (205 aa)    
Predicted Functional Partners:
atg13
Autophagy-related protein 13; Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).
    
 0.997
atg1
Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...]
    
 0.996
Pc12g16470
Pc12g16470 protein.
     
 0.980
Pc22g20500
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
     
 0.974
Pc16g03300
Pc16g03300 protein.
     
 0.969
Pc13g09040
Pc13g09040 protein.
    
 0.961
Pc20g09510
Pc20g09510 protein.
    
 0.910
Pc21g20690
Serine/threonine-protein phosphatase.
     
  0.900
Pc21g00590
Phosphatidylinositol 3-kinase VPS34.
    
 0.867
Pc21g21790
Pc21g21790 protein.
     
 0.860
Your Current Organism:
Penicillium rubens
NCBI taxonomy Id: 500485
Other names: P. rubens Wisconsin 54-1255, Penicillium rubens Wisconsin 54-1255
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.