STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribB3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa)    
Predicted Functional Partners:
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 0.999
ribE
KEGG: spn:SP_0177 3.2e-64 riboflavin synthase, alpha subunit K00793.
 
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
folE
GTP cyclohydrolase I; KEGG: chy:CHY_0955 1.2e-71 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.956
MoaA
Putative molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.903
GuaB_2
Putative inosine-5'-monophosphate dehydrogenase; KEGG: lin:lin0179 7.6e-221 similar to inosine monophosphate dehydrogenase K00088; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.862
RelA_2
Hypothetical protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
  0.829
nrdD
KEGG: sfx:S4514 8.1e-130 nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; Psort location: Cytoplasmic, score: 8.87.
    
  0.801
nrdD-2
KEGG: pac:PPA2137 1.9e-233 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 8.87.
    
  0.801
pyk
Pyruvate kinase; KEGG: tte:TTE1815 8.3e-192 pykF; pyruvate kinase K00873; Psort location: Cytoplasmic, score: 8.87.
     
  0.800
Your Current Organism:
Clostridium hiranonis
NCBI taxonomy Id: 500633
Other names: Clostridium hiranonis DSM 13275, Clostridium hiranonis str. DSM 13275, Clostridium hiranonis strain DSM 13275, [. hiranonis DSM 13275, [Clostridium] hiranonis DSM 13275
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