node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEX68373.1 | clpP | MITSMUL_04956 | MITSMUL_03605 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.943 |
EEX68373.1 | dnaJ | MITSMUL_04956 | MITSMUL_04723 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.846 |
EEX68373.1 | dnaK | MITSMUL_04956 | MITSMUL_04722 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.966 |
EEX68373.1 | groL | MITSMUL_04956 | MITSMUL_03417 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.579 |
EEX68373.1 | groS | MITSMUL_04956 | MITSMUL_03418 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.589 |
EEX68373.1 | grpE | MITSMUL_04956 | MITSMUL_04721 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.799 |
EEX68373.1 | hrcA | MITSMUL_04956 | MITSMUL_04720 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.511 |
EEX69778.1 | clpP | MITSMUL_03829 | MITSMUL_03605 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.945 |
EEX69778.1 | dnaJ | MITSMUL_03829 | MITSMUL_04723 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.839 |
EEX69778.1 | dnaK | MITSMUL_03829 | MITSMUL_04722 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.971 |
EEX69778.1 | groL | MITSMUL_03829 | MITSMUL_03417 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.559 |
EEX69778.1 | groS | MITSMUL_03829 | MITSMUL_03418 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.572 |
EEX69778.1 | grpE | MITSMUL_03829 | MITSMUL_04721 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.791 |
EEX69778.1 | hrcA | MITSMUL_03829 | MITSMUL_04720 | ATPase family associated with various cellular activities (AAA); Psort location: Cytoplasmic, score: 9.97. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.490 |
clpB | clpP | MITSMUL_03197 | MITSMUL_03605 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.936 |
clpB | dnaJ | MITSMUL_03197 | MITSMUL_04723 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.846 |
clpB | dnaK | MITSMUL_03197 | MITSMUL_04722 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.966 |
clpB | groL | MITSMUL_03197 | MITSMUL_03417 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.579 |
clpB | groS | MITSMUL_03197 | MITSMUL_03418 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.589 |
clpB | grpE | MITSMUL_03197 | MITSMUL_04721 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.799 |