STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)    
Predicted Functional Partners:
hisE
phosphoribosyl-ATP diphosphatase; KEGG: ype:YPO1542 2.8e-81 hisI, hisIE; histidine biosynthesis bifunctional protein [includes: phosphoribosyl-amp cyclohydrolase K01496:K01523; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisB
Histidinol-phosphatase; KEGG: eca:ECA2585 1.1e-157 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089:K01693; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
  
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.996
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.995
hisA
KEGG: eca:ECA2587 9.0e-99 hisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase K01814; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.995
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.995
hisC
Histidinol-phosphate transaminase; KEGG: plu:plu1569 1.2e-133 hisD; histidinol dehydrogenase K00013:K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.988
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.868
HisC2
Putative histidinol-phosphate transaminase; KEGG: eca:ECA2250 6.5e-73 putative aminotransferase K00817.
 
  
 0.852
hisS
histidine--tRNA ligase; KEGG: plu:plu1377 4.4e-193 hisS; histidine-tRNA ligase K01892.
  
 
 0.832
Your Current Organism:
Providencia rustigianii
NCBI taxonomy Id: 500637
Other names: P. rustigianii DSM 4541, Providencia rustigianii DSM 4541, Providencia rustigianii str. DSM 4541, Providencia rustigianii strain DSM 4541
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