node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFC57907.1 | EFC57990.1 | ENTCAN_05347 | ENTCAN_05431 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 0.571 |
EFC57907.1 | ilvC | ENTCAN_05347 | ENTCAN_09654 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.879 |
EFC57907.1 | ilvN | ENTCAN_05347 | ENTCAN_05127 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, small subunit; KEGG: ent:Ent638_0625 1.0e-77 ilvH; acetolactate synthase 3 regulatory subunit K01653; Psort location: Cytoplasmic, score: 8.96. | 0.749 |
EFC57907.1 | leuA | ENTCAN_05347 | ENTCAN_05131 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.794 |
EFC57907.1 | leuA-2 | ENTCAN_05347 | ENTCAN_08658 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.706 |
EFC57907.1 | leuB | ENTCAN_05347 | ENTCAN_05132 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.897 |
EFC57907.1 | leuC | ENTCAN_05347 | ENTCAN_05133 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.921 |
EFC57907.1 | leuD | ENTCAN_05347 | ENTCAN_05134 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.861 |
EFC57907.1 | thrC | ENTCAN_05347 | ENTCAN_05199 | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Threonine synthase; KEGG: ent:Ent638_0566 1.1e-215 threonine synthase K01733. | 0.442 |
EFC57990.1 | EFC57907.1 | ENTCAN_05431 | ENTCAN_05347 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.571 |
EFC57990.1 | ilvC | ENTCAN_05431 | ENTCAN_09654 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.759 |
EFC57990.1 | ilvD | ENTCAN_05431 | ENTCAN_09651 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | KEGG: kpe:KPK_5410 0. ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family. | 0.620 |
EFC57990.1 | ilvN | ENTCAN_05431 | ENTCAN_05127 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit; KEGG: ent:Ent638_0625 1.0e-77 ilvH; acetolactate synthase 3 regulatory subunit K01653; Psort location: Cytoplasmic, score: 8.96. | 0.977 |
EFC57990.1 | leuA | ENTCAN_05431 | ENTCAN_05131 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.894 |
EFC57990.1 | leuA-2 | ENTCAN_05431 | ENTCAN_08658 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.868 |
EFC57990.1 | leuB | ENTCAN_05431 | ENTCAN_05132 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.620 |
EFC57990.1 | leuC | ENTCAN_05431 | ENTCAN_05133 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.904 |
EFC57990.1 | leuD | ENTCAN_05431 | ENTCAN_05134 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.912 |
ilvC | EFC57907.1 | ENTCAN_09654 | ENTCAN_05347 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Putative dehydratase, YjhG/YagF family; KEGG: eco:b0269 0. yagF, ECK0270, JW0262; CP4-6 prophage; predicted dehydratase; K01687 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.879 |
ilvC | EFC57990.1 | ENTCAN_09654 | ENTCAN_05431 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein; KEGG: ent:Ent638_1387 5.9e-295 pyruvate dehydrogenase K00156; Psort location: Cytoplasmic, score: 8.96; Belongs to the TPP enzyme family. | 0.759 |