STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sufSBifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)    
Predicted Functional Partners:
sufE
Fe-S metabolism associated domain protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 0.995
sufB
FeS assembly protein SufB; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.994
sufD
FeS assembly protein SufD.
 
 
 0.994
sufC
KEGG: noc:Noc_2489 2.3e-87 FeS assembly ATPase SufC K09013; Psort location: CytoplasmicMembrane, score: 8.02.
 
  
 0.993
iscU
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.962
trxB
KEGG: ent:Ent638_1412 3.8e-165 thioredoxin reductase; K00384 thioredoxin reductase (NADPH); Psort location: Cytoplasmic, score: 9.97.
 
 
 0.927
selD
Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP.
   
 0.915
metB
KEGG: ent:Ent638_4035 1.4e-197 cystathionine gamma-synthase K01739; Psort location: Cytoplasmic, score: 9.26.
     
 0.901
sufA
FeS assembly scaffold SufA; KEGG: hiq:CGSHiGG_02350 3.6e-11 iron-sulfur cluster insertion protein ErpA; Belongs to the HesB/IscA family.
  
 
 0.851
csdE
KEGG: ecm:EcSMS35_2952 1.6e-56 csdE; cysteine desulfurase, sulfur acceptor subunit CsdE.
 
 
 0.836
Your Current Organism:
Enterobacter cancerogenus
NCBI taxonomy Id: 500639
Other names: E. cancerogenus ATCC 35316, Enterobacter cancerogenus ATCC 35316, Enterobacter cancerogenus str. ATCC 35316, Enterobacter cancerogenus strain ATCC 35316
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