node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFC54064.1 | glnE | ENTCAN_09046 | ENTCAN_09045 | Adenylate cyclase; KEGG: sew:SeSA_A3392 7.2e-171 adenylate cyclase. | [Glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | 0.753 |
EFC54064.1 | rfaE | ENTCAN_09046 | ENTCAN_09044 | Adenylate cyclase; KEGG: sew:SeSA_A3392 7.2e-171 adenylate cyclase. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.640 |
RfaQ | diaA | ENTCAN_08243 | ENTCAN_09164 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | 0.716 |
RfaQ | gmhA | ENTCAN_08243 | ENTCAN_07325 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. | 0.718 |
RfaQ | kdsD | ENTCAN_08243 | ENTCAN_09215 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | KEGG: ent:Ent638_3633 7.3e-162 D-arabinose 5-phosphate isomerase K06041; Psort location: Cytoplasmic, score: 8.96. | 0.618 |
RfaQ | lpxB | ENTCAN_08243 | ENTCAN_05015 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.562 |
RfaQ | rfaC | ENTCAN_08243 | ENTCAN_08248 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | Lipopolysaccharide heptosyltransferase I; KEGG: ent:Ent638_0115 1.7e-130 ADP-heptose:LPS heptosyl transferase I; K02841 heptosyltransferase I. | 0.975 |
RfaQ | rfaD | ENTCAN_08243 | ENTCAN_08250 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.734 |
RfaQ | rfaE | ENTCAN_08243 | ENTCAN_09044 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.820 |
RfaQ | rfaF | ENTCAN_08243 | ENTCAN_08249 | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | KEGG: ent:Ent638_0116 2.1e-180 ADP-heptose:LPS heptosyltransferase II; K02843 heptosyltransferase II. | 0.980 |
diaA | RfaQ | ENTCAN_09164 | ENTCAN_08243 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | 0.716 |
diaA | kdsD | ENTCAN_09164 | ENTCAN_09215 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | KEGG: ent:Ent638_3633 7.3e-162 D-arabinose 5-phosphate isomerase K06041; Psort location: Cytoplasmic, score: 8.96. | 0.466 |
diaA | lpxB | ENTCAN_09164 | ENTCAN_05015 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.424 |
diaA | rfaC | ENTCAN_09164 | ENTCAN_08248 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Lipopolysaccharide heptosyltransferase I; KEGG: ent:Ent638_0115 1.7e-130 ADP-heptose:LPS heptosyl transferase I; K02841 heptosyltransferase I. | 0.501 |
diaA | rfaD | ENTCAN_09164 | ENTCAN_08250 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.743 |
diaA | rfaE | ENTCAN_09164 | ENTCAN_09044 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.933 |
diaA | rfaF | ENTCAN_09164 | ENTCAN_08249 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | KEGG: ent:Ent638_0116 2.1e-180 ADP-heptose:LPS heptosyltransferase II; K02843 heptosyltransferase II. | 0.751 |
glnE | EFC54064.1 | ENTCAN_09045 | ENTCAN_09046 | [Glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | Adenylate cyclase; KEGG: sew:SeSA_A3392 7.2e-171 adenylate cyclase. | 0.753 |
glnE | rfaE | ENTCAN_09045 | ENTCAN_09044 | [Glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.680 |
gmhA | RfaQ | ENTCAN_07325 | ENTCAN_08243 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. | KEGG: spe:Spro_4832 1.6e-127 lipopolysaccharide heptosyltransferase III, putative; K02849 heptosyltransferase III; Psort location: CytoplasmicMembrane, score: 9.82. | 0.718 |