STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (256 aa)    
Predicted Functional Partners:
cysC
Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.
 
 
 0.986
cysD
KEGG: kpe:KPK_1009 1.5e-161 cysD; sulfate adenylyltransferase subunit 2 K00957; Psort location: Cytoplasmic, score: 8.96.
 
 0.964
cysN
Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
 
 0.950
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
  
 
 0.939
cpdB
KEGG: ent:Ent638_0392 0. cpdB; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; K01119 2',3'-cyclic-nucleotide 2'-phosphodiesterase K08693; Psort location: Periplasmic, score: 10.00; Belongs to the 5'-nucleotidase family.
       0.567
EFC56209.1
KEGG: kpn:KPN_02865 1.0e-130 suhB; inositol monophosphatase; K01092 myo-inositol-1(or 4)-monophosphatase; Psort location: Cytoplasmic, score: 8.96.
 
   
0.543
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
    0.494
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
      
 0.487
cobA
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
  
 0.483
putP
Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.433
Your Current Organism:
Enterobacter cancerogenus
NCBI taxonomy Id: 500639
Other names: E. cancerogenus ATCC 35316, Enterobacter cancerogenus ATCC 35316, Enterobacter cancerogenus str. ATCC 35316, Enterobacter cancerogenus strain ATCC 35316
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.