STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A3F2Y4R5Uncharacterized protein. (334 aa)    
Predicted Functional Partners:
GET3
ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]
    
 0.997
A0A3F2XYI2
Uncharacterized protein.
    
   0.953
A0A3F2XYQ4
TPR_REGION domain-containing protein.
   
 0.952
A0A3F2Y3T0
Uncharacterized protein.
    
 0.938
A0A3F2Y7X1
TPR_REGION domain-containing protein.
   
 0.895
A0A3F2Y2H6
Uncharacterized protein.
    
 0.850
A0A3F2Y6R7
PH domain-containing protein.
    
 0.782
GET1
Golgi to ER traffic protein 1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
    
 0.656
A0A3F2XZ23
Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
    
   0.612
A0A3F2YA63
Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
    
   0.612
Your Current Organism:
Brettanomyces bruxellensis
NCBI taxonomy Id: 5007
Other names: ATCC 36234, B. bruxellensis, Brettanomyces custersii, CBS 72, CBS 74, CCRC 21414, CCRC:21414, DBVPG 6706, Dekkera bruxellensis, Dekkera intermedia, NCYC 823, NRRL Y-12961
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