Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
OOC53170.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (559 aa)    
Predicted Functional Partners:
OOC52548.1
Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.997
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.986
OOC52547.1
Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.958
OOC52551.1
Catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.953
OOC54082.1
Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.935
OOC56688.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.928
OOC54058.1
Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.923
OOC57426.1
2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.891
NOSIN_00835
Permease; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
  0.815
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.807
Your Current Organism:
Nocardiopsis sinuspersici
NCBI taxonomy Id: 501010
Other names: CCUG 57624, DSM 45277, N. sinuspersici, Nocardiopsis sinuspersici Hamedi et al. 2010, Nocardiopsis sp. HM6, UTMC 00102, strain HM6
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