STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaKUnannotated protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (612 aa)    
Predicted Functional Partners:
dnaJ
Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
 0.999
grpE
Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]
 
 0.999
htpG
Unannotated protein; Molecular chaperone. Has ATPase activity.
 
 0.999
B5F15_00645
Unannotated protein.
 
 0.998
groL
Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.993
B5F15_04005
Unannotated protein; Belongs to the ClpA/ClpB family.
  
 
 0.989
hrcA
Unannotated protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.982
B5F15_02005
Unannotated protein; Belongs to the ClpA/ClpB family.
  
 
 0.980
B5F15_14935
Unannotated protein.
  
 0.978
GCA_900143195_01418
Unannotated protein.
  
 0.978
Your Current Organism:
Butyricicoccus pullicaecorum
NCBI taxonomy Id: 501571
Other names: B. pullicaecorum, Butyricicoccus pullicaecorum Eeckhaut et al. 2008, CCUG 55265, Clostridiaceae bacterium 25-3, DSM 23266, LMG 24109, LMG:24109, strain 25-3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.