Hoch_2405 protein (Haliangium ochraceum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Score

Hoch_2405

Hypothetical protein. (46 aa)

Predicted Functional Partners:

Hoch_2406

0.560

Hoch_2407

0.457

Hoch_2408

0.457

Hoch_2403

0.418

Hoch_2404

0.418

Your Current Organism:

Haliangium ochraceum

NCBI taxonomy Id: 502025
Other names: H. ochraceum DSM 14365, Haliangium ochraceum DSM 14365, Haliangium ochraceum SMP-2, Haliangium ochraceum str. DSM 14365, Haliangium ochraceum strain DSM 14365, myxobacterium SMP-2

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Hoch_2403	Hoch_2404	PFAM: SH3 type 3 domain protein; KEGG: tgr:Tgr7_0549 hypothetical protein.	KEGG: tgr:Tgr7_0550 hypothetical protein.	0.773
Hoch_2403	Hoch_2405	PFAM: SH3 type 3 domain protein; KEGG: tgr:Tgr7_0549 hypothetical protein.	Hypothetical protein.	0.418
Hoch_2404	Hoch_2403	KEGG: tgr:Tgr7_0550 hypothetical protein.	PFAM: SH3 type 3 domain protein; KEGG: tgr:Tgr7_0549 hypothetical protein.	0.773
Hoch_2404	Hoch_2405	KEGG: tgr:Tgr7_0550 hypothetical protein.	Hypothetical protein.	0.418
Hoch_2405	Hoch_2403	Hypothetical protein.	PFAM: SH3 type 3 domain protein; KEGG: tgr:Tgr7_0549 hypothetical protein.	0.418
Hoch_2405	Hoch_2404	Hypothetical protein.	KEGG: tgr:Tgr7_0550 hypothetical protein.	0.418
Hoch_2405	Hoch_2406	Hypothetical protein.	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	0.560
Hoch_2405	Hoch_2407	Hypothetical protein.	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	0.457
Hoch_2405	Hoch_2408	Hypothetical protein.	Hypothetical protein.	0.457
Hoch_2406	Hoch_2405	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	Hypothetical protein.	0.560
Hoch_2406	Hoch_2407	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	0.618
Hoch_2406	Hoch_2408	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	Hypothetical protein.	0.618
Hoch_2407	Hoch_2405	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	Hypothetical protein.	0.457
Hoch_2407	Hoch_2406	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	0.618
Hoch_2407	Hoch_2408	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	Hypothetical protein.	0.773
Hoch_2408	Hoch_2405	Hypothetical protein.	Hypothetical protein.	0.457
Hoch_2408	Hoch_2406	Hypothetical protein.	PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: scl:sce5780 hypothetical protein.	0.618
Hoch_2408	Hoch_2407	Hypothetical protein.	PFAM: Polynucleotide adenylyltransferase region; KEGG: ank:AnaeK_2387 tRNA cytidylyltransferase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	0.773

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045039

Protein insertion into mitochondrial inner membrane

3 of 7

3.0

2.53

2.54e-05

GO:0046834

Lipid phosphorylation

2 of 2

3.37

1.79

0.00060

GO:0046512

Sphingosine biosynthetic process

2 of 5

2.97

1.59

0.0013

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

2 of 6

2.89

1.59

0.0013

GO:0006099

Tricarboxylic acid cycle

2 of 29

2.2

1.05

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140318

Protein transporter activity

3 of 25

2.44

1.87

0.00032

GO:0004402

Histone acetyltransferase activity

2 of 23

2.3

0.85

0.0274

GO:0140110

Transcription regulator activity

4 of 412

1.35

0.78

0.0171

GO:0046872

Metal ion binding

6 of 2233

0.79

0.46

0.0331

GO:0005488

Binding

10 of 7866

0.47

0.32

0.0274

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042721

TIM22 mitochondrial import inner membrane insertion complex

3 of 4

3.24

3.32

9.53e-07

GO:0098800

Inner mitochondrial membrane protein complex

5 of 120

1.99

2.79

9.53e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 3

3.19

2.13

0.00014

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 5

2.97

1.98

0.00026

GO:0032991

Protein-containing complex

6 of 2897

0.68

0.45

0.0164

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24142

Tim10-like, and TIM22 mitochondrial import inner membrane insertion complex

3 of 7

3.0

2.59

1.96e-05

CL:19911

Fumarate reductase complex

2 of 5

2.97

1.48

0.0021

CL:1544

Mixed, incl. Lectin, and Met-10+ like-protein

2 of 11

2.63

1.31

0.0040

CL:21436

Sphingolipid metabolism

2 of 18

2.41

1.12

0.0088

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 72

1.99

1.25

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 4

3.06

1.6

0.0013

GOCC:0045281

Succinate dehydrogenase complex

2 of 7

2.82

1.52

0.0017

GOCC:0098798

Mitochondrial protein complex

4 of 184

1.7

1.42

0.00090

GOCC:0005740

Mitochondrial envelope

4 of 367

1.4

1.12

0.0019

GOCC:0098800

Inner mitochondrial membrane protein complex

2 of 75

1.79

0.82

0.0255

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 13

2.55

1.41

0.0026

KW-0496

Mitochondrion

3 of 102

1.83

1.28

0.0026

KW-1015

Disulfide bond

2 of 92

1.7

0.7

0.0428

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

2 of 4

3.06

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034804

Fumarate reductase/succinate dehydrogenase, transmembrane subunit

2 of 3

3.19

1.39

0.0032

IPR001206

Diacylglycerol kinase, catalytic domain

2 of 2

3.37

1.39

0.0032

IPR035427

Tim10-like domain superfamily

2 of 4

3.06

1.38

0.0032

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

2 of 5

2.97

1.38

0.0032

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

2 of 5

2.97

1.38

0.0032

(more ...)

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