STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (260 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.982
Hoch_2553
PFAM: chaperone DnaJ domain protein; heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: mxa:MXAN_0750 chaperone protein DnaJ.
 
 
 0.968
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 
 0.934
dnaK-2
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.917
Hoch_0424
PFAM: Heat shock protein 70; KEGG: gsu:GSU0033 molecular chaperone DnaK.
 
 0.915
Hoch_0392
PFAM: Heat shock protein 70; KEGG: scl:sce2420 Hsp70 heat shock protein.
 
 0.912
Hoch_6054
PFAM: Heat shock protein 70; KEGG: cvi:CV_1643 molecular chaperone DnaK.
 
 0.906
Hoch_3642
PFAM: Heat shock protein 70; KEGG: hha:Hhal_0145 heat shock protein 70.
 
 0.901
Hoch_5925
PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bba:Bd3872 DnaJ protein.
 
 
 0.876
Hoch_0242
PFAM: Heat shock protein 70; KEGG: scl:sce7648 Hsp70 heat shock protein.
 
 0.874
Your Current Organism:
Haliangium ochraceum
NCBI taxonomy Id: 502025
Other names: H. ochraceum DSM 14365, Haliangium ochraceum DSM 14365, Haliangium ochraceum SMP-2, Haliangium ochraceum str. DSM 14365, Haliangium ochraceum strain DSM 14365, myxobacterium SMP-2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.