STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hoch_5169PFAM: 5'-3' exonuclease, SAM-fold domain; 5'-3' exonuclease, N-terminal resolvase-like domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: mxa:MXAN_0335 5'-3' exonuclease family protein. (294 aa)    
Predicted Functional Partners:
Hoch_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.975
Hoch_5692
PFAM: 3'-5' exonuclease, PolB-like; KEGG: nis:NIS_1414 polysaccharide biosynthesis protein.
  
 0.916
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
   
 0.901
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.891
Hoch_5168
KEGG: smt:Smal_0717 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen.
   
   0.784
Hoch_6605
DNA-directed DNA polymerase; KEGG: mca:MCA1213 hypothetical protein; PFAM: PHP domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1.
   
 0.712
Hoch_1325
PFAM: WD40 repeat, subgroup; NB-ARC domain protein; metallophosphoesterase; SMART: WD-40 repeat protein; Pyrrolo-quinoline quinone beta-propeller repeat; KEGG: scl:sce3630 WD repeat-containing protein.
  
 0.705
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.695
recA-2
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.688
Hoch_3330
TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; DNA primase small subunit; ATP dependent DNA ligase domain protein; KEGG: afw:Anae109_0939 DNA ligase D.
  
 0.682
Your Current Organism:
Haliangium ochraceum
NCBI taxonomy Id: 502025
Other names: H. ochraceum DSM 14365, Haliangium ochraceum DSM 14365, Haliangium ochraceum SMP-2, Haliangium ochraceum str. DSM 14365, Haliangium ochraceum strain DSM 14365, myxobacterium SMP-2
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.