node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OAZ11495.1 | OAZ12292.1 | TH15_18735 | TH15_17040 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.613 |
OAZ11495.1 | OAZ13193.1 | TH15_18735 | TH15_12005 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
OAZ11495.1 | OAZ14656.1 | TH15_18735 | TH15_02275 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
OAZ11495.1 | OAZ14975.1 | TH15_18735 | TH15_04065 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
OAZ11495.1 | folD | TH15_18735 | TH15_09260 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.466 |
OAZ11495.1 | folE | TH15_18735 | TH15_06765 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.992 |
OAZ11495.1 | thyA | TH15_18735 | TH15_17035 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.652 |
OAZ12292.1 | OAZ11495.1 | TH15_17040 | TH15_18735 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.613 |
OAZ12292.1 | OAZ14975.1 | TH15_17040 | TH15_04065 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.946 |
OAZ12292.1 | folD | TH15_17040 | TH15_09260 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.554 |
OAZ12292.1 | thyA | TH15_17040 | TH15_17035 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
OAZ13193.1 | OAZ11495.1 | TH15_12005 | TH15_18735 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
OAZ13193.1 | OAZ14656.1 | TH15_12005 | TH15_02275 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
OAZ13193.1 | OAZ14975.1 | TH15_12005 | TH15_04065 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.875 |
OAZ13193.1 | folE | TH15_12005 | TH15_06765 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.978 |
OAZ14656.1 | OAZ11495.1 | TH15_02275 | TH15_18735 | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
OAZ14656.1 | OAZ13193.1 | TH15_02275 | TH15_12005 | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
OAZ14656.1 | OAZ14975.1 | TH15_02275 | TH15_04065 | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.847 |
OAZ14656.1 | folE | TH15_02275 | TH15_06765 | Dihydroneopterin aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.973 |
OAZ14975.1 | OAZ11495.1 | TH15_04065 | TH15_18735 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |