node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KPA87390.1 | KPA90185.1 | PF66_06020 | PF66_03318 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 0.824 |
KPA87390.1 | KPA92757.1 | PF66_06020 | PF66_00496 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. | 0.728 |
KPA87390.1 | gcvH | PF66_06020 | PF66_00494 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.972 |
KPA87390.1 | gcvP | PF66_06020 | PF66_00495 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating) alpha/beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.996 |
KPA87390.1 | glyA | PF66_06020 | PF66_04371 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
KPA87390.1 | glyA-2 | PF66_06020 | PF66_06017 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
KPA87390.1 | serC | PF66_06020 | PF66_04697 | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.430 |
KPA90185.1 | KPA87390.1 | PF66_03318 | PF66_06020 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. | 0.824 |
KPA90185.1 | KPA92528.1 | PF66_03318 | PF66_01208 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | 0.854 |
KPA90185.1 | KPA92757.1 | PF66_03318 | PF66_00496 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. | 0.761 |
KPA90185.1 | KPA92904.1 | PF66_03318 | PF66_00645 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain'. | 0.849 |
KPA90185.1 | glyA | PF66_03318 | PF66_04371 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.835 |
KPA90185.1 | glyA-2 | PF66_03318 | PF66_06017 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.835 |
KPA90185.1 | serC | PF66_03318 | PF66_04697 | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.779 |
KPA92528.1 | KPA90185.1 | PF66_01208 | PF66_03318 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | Cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 0.854 |
KPA92528.1 | KPA92757.1 | PF66_01208 | PF66_00496 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. | 0.830 |
KPA92528.1 | KPA92904.1 | PF66_01208 | PF66_00645 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain'. | 0.847 |
KPA92528.1 | gcvP | PF66_01208 | PF66_00495 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | Glycine dehydrogenase (decarboxylating) alpha/beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.401 |
KPA92528.1 | glyA | PF66_01208 | PF66_04371 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
KPA92528.1 | glyA-2 | PF66_01208 | PF66_06017 | Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |