Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KPA91209.1Topoisomerase IB; 'PFAM: Eukaryotic DNA topoisomerase I, catalytic core'. (339 aa)    
Predicted Functional Partners:
KPA87572.1
PFAM: Eukaryotic and archaeal DNA primase small subunit; ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; DNA polymerase Ligase (LigD); 'TIGRFAM: DNA ligase D; DNA ligase D, ligase domain; DNA ligase D, polymerase domain; DNA ligase D, 3-phosphoesterase domain'.
 
 
 0.861
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.840
KPA88619.1
ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; 'TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family'.
    
 
 0.834
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.809
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.791
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.791
KPA89782.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.778
KPA89094.1
DNA polymerase elongation subunit (family B); 'PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain'.
    
 
 0.777
KPA88643.1
Protein chain release factor B; PFAM: RF-1 domain.
  
 
   0.729
rnd
Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.
   
   0.715
Your Current Organism:
Pseudomonas fuscovaginae
NCBI taxonomy Id: 50340
Other names: CCUG 32780, CFBP 2065, CIP 106695, DSM 7231, ICMP 5940, LMG 2158, LMG:2158, NCPPB 3085, P. fuscovaginae, PDDCC 5940, PDDCC:5940, Pseudomonas fuscivaginae, strain 6801
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