node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A2B4SDY7 | IMPDH2 | A0A2B4SDY7 | A0A2B4RS01 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.935 |
A0A2B4SDY7 | TPMT | A0A2B4SDY7 | A0A2B4SMB5 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Thiopurine S-methyltransferase. | 0.919 |
IMPDH2 | A0A2B4SDY7 | A0A2B4RS01 | A0A2B4SDY7 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.935 |
IMPDH2 | TPMT | A0A2B4RS01 | A0A2B4SMB5 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Thiopurine S-methyltransferase. | 0.905 |
TPMT | A0A2B4SDY7 | A0A2B4SMB5 | A0A2B4SDY7 | Thiopurine S-methyltransferase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.919 |
TPMT | IMPDH2 | A0A2B4SMB5 | A0A2B4RS01 | Thiopurine S-methyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.905 |
TPMT | XDH | A0A2B4SMB5 | A0A2B4RDK9 | Thiopurine S-methyltransferase. | Xanthine dehydrogenase/oxidase. | 0.904 |
TPMT | pks16 | A0A2B4SMB5 | A0A2B4R535 | Thiopurine S-methyltransferase. | Putative polyketide synthase 16. | 0.500 |
TPMT | pks16-2 | A0A2B4SMB5 | A0A2B4T0I0 | Thiopurine S-methyltransferase. | Putative polyketide synthase 16. | 0.500 |
TPMT | pks2 | A0A2B4SMB5 | A0A2B4SJJ9 | Thiopurine S-methyltransferase. | Phthioceranic/hydroxyphthioceranic acid synthase. | 0.500 |
XDH | TPMT | A0A2B4RDK9 | A0A2B4SMB5 | Xanthine dehydrogenase/oxidase. | Thiopurine S-methyltransferase. | 0.904 |
pks16 | TPMT | A0A2B4R535 | A0A2B4SMB5 | Putative polyketide synthase 16. | Thiopurine S-methyltransferase. | 0.500 |
pks16 | pks16-2 | A0A2B4R535 | A0A2B4T0I0 | Putative polyketide synthase 16. | Putative polyketide synthase 16. | 0.924 |
pks16 | pks2 | A0A2B4R535 | A0A2B4SJJ9 | Putative polyketide synthase 16. | Phthioceranic/hydroxyphthioceranic acid synthase. | 0.927 |
pks16-2 | TPMT | A0A2B4T0I0 | A0A2B4SMB5 | Putative polyketide synthase 16. | Thiopurine S-methyltransferase. | 0.500 |
pks16-2 | pks16 | A0A2B4T0I0 | A0A2B4R535 | Putative polyketide synthase 16. | Putative polyketide synthase 16. | 0.924 |
pks16-2 | pks2 | A0A2B4T0I0 | A0A2B4SJJ9 | Putative polyketide synthase 16. | Phthioceranic/hydroxyphthioceranic acid synthase. | 0.925 |
pks2 | TPMT | A0A2B4SJJ9 | A0A2B4SMB5 | Phthioceranic/hydroxyphthioceranic acid synthase. | Thiopurine S-methyltransferase. | 0.500 |
pks2 | pks16 | A0A2B4SJJ9 | A0A2B4R535 | Phthioceranic/hydroxyphthioceranic acid synthase. | Putative polyketide synthase 16. | 0.927 |
pks2 | pks16-2 | A0A2B4SJJ9 | A0A2B4T0I0 | Phthioceranic/hydroxyphthioceranic acid synthase. | Putative polyketide synthase 16. | 0.925 |