STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slin_2042acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (636 aa)    
Predicted Functional Partners:
Slin_5036
Citrate synthase I; KEGG: scl:sce8281 hypothetical protein; TIGRFAM: citrate synthase I; PFAM: Citrate synthase.
  
 0.971
Slin_2043
PFAM: AMP-dependent synthetase and ligase; KEGG: vpa:VP1644 PrpE protein.
 
  
 
0.965
Slin_6109
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: pla:Plav_0465 3-hydroxyacyl-CoA dehydrogenase NAD-binding.
 
 0.932
Slin_2669
KEGG: acetoacetyl-CoA thiolase; K00626 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.931
Slin_6110
KEGG: aci:ACIAD2988 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.931
Slin_1742
PFAM: Aldehyde Dehydrogenase; KEGG: pol:Bpro_5303 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.928
Slin_2333
PFAM: Aldehyde Dehydrogenase; KEGG: noc:Noc_2916 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.928
Slin_3069
PFAM: Aldehyde Dehydrogenase; KEGG: dat:HRM2_38600 NAD-dependent aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
  
 0.928
Slin_5897
PFAM: pyruvate carboxyltransferase; KEGG: pat:Patl_3268 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.917
accD
acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
    
 0.914
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.