STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa)    
Predicted Functional Partners:
Slin_4204
DNA-(apurinic or apyrimidinic site) lyase; KEGG: mxa:MXAN_6425 base excision DNA repair protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein.
  
  
 
0.923
Slin_1733
PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; KEGG: mpo:Mpop_2840 HhH-GPD family protein.
  
  
 
0.922
Slin_0521
KEGG: bba:Bd3524 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
 0.866
Slin_1134
PFAM: periplasmic binding protein; KEGG: bxe:Bxe_A4249 iron ABC transporter periplasmic ligand-binding protein.
      0.635
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 0.594
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.588
Slin_5592
PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; KEGG: predicted protein; K10563 formamidopyrimidine- DNA glycosylase; Belongs to the FPG family.
   
  
 0.564
Slin_6032
RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: scl:sce5947 RNA polymerase sigma factor; Belongs to the sigma-70 factor family. ECF subfamily.
       0.539
Slin_6031
Hypothetical protein.
       0.531
Slin_5744
Dimethylallyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: sit:TM1040_3742 farnesyltranstransferase; Belongs to the FPP/GGPP synthase family.
 
    0.441
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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