STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slin_6250PFAM: bifunctional deaminase-reductase domain protein; KEGG: hch:HCH_05422 dihydrofolate reductase. (182 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.770
Slin_6249
PFAM: protein of unknown function DUF34; KEGG: aeh:Mlg_2212 hypothetical protein.
       0.576
Slin_0839
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: fph:Fphi_0487 glyoxalase family protein.
 
  
 0.422
Slin_3076
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vsp:VS_II0095 glyoxalase/bleomycin resistance protein/dioxygenase.
 
  
 0.415
Slin_6251
TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; KEGG: mxa:MXAN_7119 MATE efflux family protein.
       0.412
Slin_0464
Transcriptional regulator, MerR family; PFAM: TipAS antibiotic-recognition domain protein; regulatory protein MerR; Transcription regulator MerR DNA binding; SMART: regulatory protein MerR; KEGG: lpp:plpp0088 hypothetical protein.
  
     0.404
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.