AGK04408.1 protein (Meiothermus ruber) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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protein homology

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Score

AGK04408.1

Hypothetical protein; COG5621 Predicted secreted hydrolase. (355 aa)

Predicted Functional Partners:

AGK04409.1

0.543

AGK05092.1

0.507

AGK03615.1

0.481

AGK03902.1

0.476

AGK05315.1

0.460

Your Current Organism:

Meiothermus ruber

NCBI taxonomy Id: 504728
Other names: M. ruber DSM 1279, Meiothermus ruber ATCC 35948, Meiothermus ruber DSM 1279

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGK03615.1	AGK04408.1	K649_01555	K649_05530	FAD dependent oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins.	Hypothetical protein; COG5621 Predicted secreted hydrolase.	0.481
AGK03615.1	AGK05092.1	K649_01555	K649_08995	FAD dependent oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins.	COG1233 Phytoene dehydrogenase and related proteins.	0.624
AGK03902.1	AGK04408.1	K649_03000	K649_05530	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein; COG5621 Predicted secreted hydrolase.	0.476
AGK03902.1	AGK05315.1	K649_03000	K649_10115	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.685
AGK04408.1	AGK03615.1	K649_05530	K649_01555	Hypothetical protein; COG5621 Predicted secreted hydrolase.	FAD dependent oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins.	0.481
AGK04408.1	AGK03902.1	K649_05530	K649_03000	Hypothetical protein; COG5621 Predicted secreted hydrolase.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.476
AGK04408.1	AGK04409.1	K649_05530	K649_05535	Hypothetical protein; COG5621 Predicted secreted hydrolase.	Hydrolase TatD family protein; COG0084 Mg-dependent DNase.	0.543
AGK04408.1	AGK05092.1	K649_05530	K649_08995	Hypothetical protein; COG5621 Predicted secreted hydrolase.	COG1233 Phytoene dehydrogenase and related proteins.	0.507
AGK04408.1	AGK05315.1	K649_05530	K649_10115	Hypothetical protein; COG5621 Predicted secreted hydrolase.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.460
AGK04409.1	AGK04408.1	K649_05535	K649_05530	Hydrolase TatD family protein; COG0084 Mg-dependent DNase.	Hypothetical protein; COG5621 Predicted secreted hydrolase.	0.543
AGK05092.1	AGK03615.1	K649_08995	K649_01555	COG1233 Phytoene dehydrogenase and related proteins.	FAD dependent oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins.	0.624
AGK05092.1	AGK04408.1	K649_08995	K649_05530	COG1233 Phytoene dehydrogenase and related proteins.	Hypothetical protein; COG5621 Predicted secreted hydrolase.	0.507
AGK05315.1	AGK03902.1	K649_10115	K649_03000	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.685
AGK05315.1	AGK04408.1	K649_10115	K649_05530	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein; COG5621 Predicted secreted hydrolase.	0.460

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

41

PPI enrichment p-value:

0.00626

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 947

0.75

0.6

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2050

Condensation domain, and Siderophore metabolic process

6 of 24

2.22

4.15

1.96e-09

CL:2053

Condensation domain

5 of 19

2.24

3.71

2.58e-08

CL:2032

ACP-like superfamily, and Fatty acid synthase activity

7 of 113

1.62

2.64

2.58e-08

CL:2081

Ketoacyl-synthetase C-terminal extension, and Enoylreductase

3 of 5

2.6

2.59

1.47e-05

CL:2056

Condensation domain

2 of 12

2.05

0.92

0.0181

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005835

Fatty acid synthase complex

4 of 46

1.76

1.7

0.00021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

7 of 58

1.91

3.87

2.20e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00501

AMP-binding enzyme

5 of 46

1.86

2.38

5.24e-06

PF00668

Condensation domain

4 of 26

2.01

2.19

3.24e-05

PF13193

AMP-binding enzyme C-terminal domain

4 of 37

1.86

1.93

7.91e-05

PF00296

Luciferase-like monooxygenase

2 of 7

2.28

0.97

0.0161

PF00975

Thioesterase domain

2 of 9

2.17

0.92

0.0197

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

7 of 59

1.9

3.54

2.40e-09

IPR009081

Phosphopantetheine binding ACP domain

7 of 59

1.9

3.54

2.40e-09

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

6 of 47

1.93

3.23

3.46e-08

IPR006162

Phosphopantetheine attachment site

5 of 36

1.97

2.76

1.04e-06

IPR020845

AMP-binding, conserved site

5 of 42

1.9

2.6

1.70e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

5 of 29

2.06

3.22

1.24e-07

SM00826

PKS_DH

3 of 15

2.12

1.91

0.00018

SM00825

Beta-ketoacyl synthase

3 of 18

2.05

1.87

0.00019

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

3 of 19

2.02

1.86

0.00019

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

2 of 22

1.78

0.87

0.0194

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