AGK04731.1 protein (Meiothermus ruber) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

AGK04731.1

COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription. (220 aa)

Predicted Functional Partners:

AGK05547.1

0.477

AGK04732.1

0.459

AGK04137.1

0.456

AGK04301.1

0.416

AGK04497.1

0.416

AGK05956.1

0.416

AGK05234.1

0.402

Your Current Organism:

Meiothermus ruber

NCBI taxonomy Id: 504728
Other names: M. ruber DSM 1279, Meiothermus ruber ATCC 35948, Meiothermus ruber DSM 1279

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGK04137.1	AGK04301.1	K649_04175	K649_04995	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.589
AGK04137.1	AGK04497.1	K649_04175	K649_05985	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.605
AGK04137.1	AGK04731.1	K649_04175	K649_07165	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	0.456
AGK04137.1	AGK05234.1	K649_04175	K649_09710	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	GAF sensor-containing diguanylate cyclase/phosphodiesterase; COG2203 FOG: GAF domain.	0.982
AGK04137.1	AGK05956.1	K649_04175	K649_13350	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.528
AGK04301.1	AGK04137.1	K649_04995	K649_04175	Histidine kinase; COG4585 Signal transduction histidine kinase.	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	0.589
AGK04301.1	AGK04497.1	K649_04995	K649_05985	Histidine kinase; COG4585 Signal transduction histidine kinase.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.603
AGK04301.1	AGK04731.1	K649_04995	K649_07165	Histidine kinase; COG4585 Signal transduction histidine kinase.	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	0.416
AGK04301.1	AGK05234.1	K649_04995	K649_09710	Histidine kinase; COG4585 Signal transduction histidine kinase.	GAF sensor-containing diguanylate cyclase/phosphodiesterase; COG2203 FOG: GAF domain.	0.560
AGK04497.1	AGK04137.1	K649_05985	K649_04175	Histidine kinase; COG4585 Signal transduction histidine kinase.	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	0.605
AGK04497.1	AGK04301.1	K649_05985	K649_04995	Histidine kinase; COG4585 Signal transduction histidine kinase.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.603
AGK04497.1	AGK04731.1	K649_05985	K649_07165	Histidine kinase; COG4585 Signal transduction histidine kinase.	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	0.416
AGK04497.1	AGK05234.1	K649_05985	K649_09710	Histidine kinase; COG4585 Signal transduction histidine kinase.	GAF sensor-containing diguanylate cyclase/phosphodiesterase; COG2203 FOG: GAF domain.	0.560
AGK04497.1	AGK05956.1	K649_05985	K649_13350	Histidine kinase; COG4585 Signal transduction histidine kinase.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.602
AGK04731.1	AGK04137.1	K649_07165	K649_04175	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	0.456
AGK04731.1	AGK04301.1	K649_07165	K649_04995	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.416
AGK04731.1	AGK04497.1	K649_07165	K649_05985	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	Histidine kinase; COG4585 Signal transduction histidine kinase.	0.416
AGK04731.1	AGK04732.1	K649_07165	K649_07170	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	Hypothetical protein.	0.459
AGK04731.1	AGK05234.1	K649_07165	K649_09710	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	GAF sensor-containing diguanylate cyclase/phosphodiesterase; COG2203 FOG: GAF domain.	0.402
AGK04731.1	AGK05547.1	K649_07165	K649_11285	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription.	COG4371 Predicted membrane protein.	0.477

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

18

PPI enrichment p-value:

4.94e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035556

Intracellular signal transduction

6 of 251

1.49

1.72

2.45e-05

GO:0007165

Signal transduction

7 of 427

1.32

1.5

2.45e-05

GO:0010737

Protein kinase A signaling

2 of 4

2.81

1.38

0.0031

GO:0006796

Phosphate-containing compound metabolic process

6 of 765

1.0

0.77

0.0032

GO:0048519

Negative regulation of biological process

5 of 541

1.07

0.73

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

4 of 5

3.01

4.05

3.74e-08

GO:0004679

AMP-activated protein kinase activity

3 of 3

3.11

2.91

5.24e-06

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.98

2.86

6.11e-06

GO:0019003

GDP binding

2 of 3

2.93

1.48

0.0021

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 544

1.07

0.79

0.0045

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 4

2.81

1.21

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3280

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

5 of 16

2.6

4.43

3.23e-09

CL:3208

Mixed, incl. Peptidyl-serine phosphorylation, and Aquaporin-mediated transport

6 of 52

2.17

3.99

3.23e-09

CL:3282

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

4 of 11

2.67

3.66

1.31e-07

CL:3285

G protein activity, and Cyclic nucleotide-dependent protein kinase activity

3 of 5

2.89

2.8

7.61e-06

CL:2922

Protein kinase domain, and GTPase regulator activity

7 of 196

1.66

2.76

2.32e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 131

1.59

1.5

0.00035

map04138

Autophagy - yeast

3 of 150

1.41

0.84

0.0135

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9634597

GPER1 signaling

3 of 4

2.98

2.88

5.70e-06

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 4

2.98

2.88

5.70e-06

MAP-164378

PKA activation in glucagon signalling

3 of 4

2.98

2.88

5.70e-06

MAP-163615

PKA activation

3 of 4

2.98

2.88

5.70e-06

MAP-163359

Glucagon signaling in metabolic regulation

3 of 4

2.98

2.88

5.70e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.89

2.59

1.86e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

2 of 4

2.81

0.91

0.0225

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

2 of 3

2.93

1.53

0.0017

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