STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kynATryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (275 aa)    
Predicted Functional Partners:
kynU
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.
 
 
 0.997
kynB
Cyclase family protein; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
 
 
 0.926
AGK05672.1
Arylformamidase; COG0657 Esterase/lipase.
 
 
 0.900
AGK05686.1
salicylyl-CoA 5-hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases.
 
 
 0.897
AGK05681.1
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
 
     0.860
AGK05680.1
Endoribonuclease L-PSP; COG0251 Putative translation initiation inhibitor, yjgF family.
 
     0.854
AGK05684.1
COG1846 Transcriptional regulators.
 
     0.841
AGK05683.1
COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family.
 
    0.840
AGK05682.1
COG1960 Acyl-CoA dehydrogenases.
 
     0.815
AGK05685.1
Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
       0.773
Your Current Organism:
Meiothermus ruber
NCBI taxonomy Id: 504728
Other names: M. ruber DSM 1279, Meiothermus ruber ATCC 35948, Meiothermus ruber DSM 1279
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.