SDI51828.1 protein (Alloactinosynnema album)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SDI51828.1

ATP-binding cassette, subfamily B. (588 aa)

Predicted Functional Partners:

SDI51843.1

0.820

SDI17234.1

0.744

SDI20421.1

0.718

SDJ39184.1

0.699

SDJ43840.1

0.686

SDJ54304.1

0.647

SDI17214.1

0.646

SDI32264.1

0.646

SDI16879.1

0.625

SDI79248.1

0.611

Your Current Organism:

Alloactinosynnema album

NCBI taxonomy Id: 504798
Other names: A. album, Alloactinosynnema album Yuan et al. 2010, Amycolatopsis sp. 03-9939, CCM 7461, DSM 45114, JCM 17965, KCTC 19294, strain 03-9939

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDI16879.1	SDI17214.1	SAMN05421871_103545	SAMN05421871_103562	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI16879.1	SDI17234.1	SAMN05421871_103545	SAMN05421871_103563	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.999
SDI16879.1	SDI32264.1	SAMN05421871_103545	SAMN05421871_104131	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI16879.1	SDI51828.1	SAMN05421871_103545	SAMN05421871_105370	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	ATP-binding cassette, subfamily B.	0.625
SDI16879.1	SDI51843.1	SAMN05421871_103545	SAMN05421871_105371	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	ABC-type multidrug transport system, ATPase and permease component.	0.625
SDI16879.1	SDI79248.1	SAMN05421871_103545	SAMN05421871_107362	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Acyl transferase domain-containing protein.	0.999
SDI17214.1	SDI16879.1	SAMN05421871_103562	SAMN05421871_103545	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI17214.1	SDI17234.1	SAMN05421871_103562	SAMN05421871_103563	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.999
SDI17214.1	SDI32264.1	SAMN05421871_103562	SAMN05421871_104131	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI17214.1	SDI51828.1	SAMN05421871_103562	SAMN05421871_105370	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	ATP-binding cassette, subfamily B.	0.646
SDI17214.1	SDI51843.1	SAMN05421871_103562	SAMN05421871_105371	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	ABC-type multidrug transport system, ATPase and permease component.	0.646
SDI17214.1	SDI79248.1	SAMN05421871_103562	SAMN05421871_107362	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Acyl transferase domain-containing protein.	0.999
SDI17234.1	SDI16879.1	SAMN05421871_103563	SAMN05421871_103545	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI17234.1	SDI17214.1	SAMN05421871_103563	SAMN05421871_103562	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI17234.1	SDI32264.1	SAMN05421871_103563	SAMN05421871_104131	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SDI17234.1	SDI51828.1	SAMN05421871_103563	SAMN05421871_105370	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	ATP-binding cassette, subfamily B.	0.744
SDI17234.1	SDI51843.1	SAMN05421871_103563	SAMN05421871_105371	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	ABC-type multidrug transport system, ATPase and permease component.	0.744
SDI17234.1	SDI79248.1	SAMN05421871_103563	SAMN05421871_107362	Ketoacyl-synthetase C-terminal extension; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Acyl transferase domain-containing protein.	0.999
SDI20421.1	SDI51828.1	SAMN05421871_103713	SAMN05421871_105370	ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.	ATP-binding cassette, subfamily B.	0.718
SDI20421.1	SDI51843.1	SAMN05421871_103713	SAMN05421871_105371	ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.	ABC-type multidrug transport system, ATPase and permease component.	0.685

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.877

expected number of edges:

21

PPI enrichment p-value:

7.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

7 of 19

2.08

4.33

1.57e-10

GO:2001295

malonyl-CoA biosynthetic process

2 of 5

2.12

1.02

0.0124

GO:0006814

Sodium ion transport

2 of 7

1.97

0.92

0.0180

GO:0044249

Cellular biosynthetic process

9 of 667

0.65

0.52

0.00085

GO:1901576

Organic substance biosynthetic process

9 of 706

0.62

0.49

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 8

2.22

2.45

1.52e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 44

1.57

1.73

5.39e-05

GO:0003989

acetyl-CoA carboxylase activity

2 of 2

2.52

1.13

0.0085

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 3

2.34

1.06

0.0113

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.12

0.91

0.0198

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 5

2.12

0.89

0.0219

GO:0005622

Intracellular anatomical structure

10 of 1227

0.43

0.31

0.0219

GO:0005737

Cytoplasm

9 of 1122

0.42

0.29

0.0361

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1452

malonyl-CoA metabolic process, and 3-oxoacyl-[acyl-carrier-protein] synthase activity

7 of 11

2.32

5.37

4.79e-12

CL:1448

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme C-terminal domain

8 of 32

1.92

4.32

6.31e-12

CL:1454

Fatty acid metabolism, and acetyl-CoA carboxylase activity

5 of 6

2.44

4.17

6.11e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

6 of 15

2.12

4.13

8.47e-10

map01212

Fatty acid metabolism

6 of 21

1.97

3.71

2.29e-09

map00620

Pyruvate metabolism

5 of 70

1.37

1.5

5.01e-05

map01200

Carbon metabolism

5 of 145

1.05

0.88

0.0012

map00780

Biotin metabolism

2 of 14

1.67

0.87

0.0178

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

4 of 9

2.17

2.53

8.98e-06

GOCC:0005737

Cytoplasm

10 of 855

0.59

0.48

0.00068

GOCC:0005622

Intracellular

11 of 1191

0.48

0.4

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

4 of 17

1.89

2.03

5.00e-05

KW-0012

Acyltransferase

3 of 17

1.76

1.37

0.0014

KW-0275

Fatty acid biosynthesis

2 of 6

2.04

1.08

0.0087

KW-0808

Transferase

6 of 311

0.8

0.57

0.0063

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