STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (448 aa)    
Predicted Functional Partners:
SDG90426.1
Succinate dehydrogenase / fumarate reductase flavoprotein subunit.
 
 0.991
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.988
SDH49673.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.974
SDG89306.1
Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.971
SDG90397.1
Succinate dehydrogenase / fumarate reductase iron-sulfur subunit.
  
 0.968
SDG90676.1
Succinate dehydrogenase / fumarate reductase iron-sulfur subunit.
  
 0.968
SDG90640.1
Succinate dehydrogenase subunit A.
 
 0.940
SDI24602.1
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
  
 0.934
SDI26422.1
Citrate synthase; Belongs to the citrate synthase family.
   
 0.934
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.930
Your Current Organism:
Sinosporangium album
NCBI taxonomy Id: 504805
Other names: DSM 45181, KCTC 19655, S. album, Sinosporangium album Zang et al. 2011, Streptosporangineae bacterium 6014, strain 6014
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